Finzer Patrick, Küppers Volkmar, Griesser Henrik
dus.ana Düsseldorf Analytik, Praxis für medizinische Mikrobiologie und Laboratoriumsmedizin, Düsseldorf, Germany.
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany.
Geburtshilfe Frauenheilkd. 2023 May 4;83(8):1017-1021. doi: 10.1055/a-2044-0162. eCollection 2023 Aug.
Human papillomavirus (HPV) infection is a necessary but not sufficient condition for the development of cervical cancer. The dysbiotic shift in the cervicovaginal microbiome appears to be a major co-factor in carcinogenesis. New analytical methods, such as next-generation sequencing (NGS), can be used to detect all of the vaginal microorganisms present and therefore identify individual therapeutic options. The relationship of bacterial vaginosis and carcinogenesis, as well as possible indications for the use of microbiome analysis, will be discussed.
人乳头瘤病毒（HPV）感染是宫颈癌发生的必要但非充分条件。宫颈阴道微生物群的生态失调转变似乎是致癌过程中的一个主要协同因素。新的分析方法，如下一代测序（NGS），可用于检测所有存在的阴道微生物，从而确定个体化治疗方案。本文将讨论细菌性阴道病与致癌作用的关系，以及微生物群分析可能的应用指征。
