Saint Sophia Hospital, Żelazna 90 Street, 01-004 Warsaw, Poland.
Department of Basic Biomedical Science, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Kasztanowa 3 Street, 41-200 Sosnowiec, Poland.
Int J Environ Res Public Health. 2021 Aug 27;18(17):9050. doi: 10.3390/ijerph18179050.
(1) Background: The microbiome consists of microorganisms from various kingdoms with numerous physical and chemical properties Lactobacillus species constitute the highest percentage of healthy cervical and vaginal microbiota. Dysbiosis may cause adverse outcomes, e.g., bacterial vaginosis, pelvic inflammatory disease and pregnancy complications. The cervicovaginal microbiome might contribute to the development of a persistent HPV infection-the main risk factor of cervical cancer-and influence progression to malignancy The aim is to perform a systematic review of current literature and a meta-analysis regarding microbiome changes after cervical intraepithelial neoplasia treatment. (2) Methods: We will search PubMed, Scopus, Google Scholar and Embase Database and trace citations in the reference sections. Randomized and non-randomized controlled studies, case-control and cohort studies published between January 2000 and May 2021 will be included in the study protocol. The following keywords will be used: 'microbiome', 'vaginal microbiome', 'cervical microbiome', 'cervical neoplasia treatment', 'conization', 'electroconization', and 'electrosurgical treatment'. Statistical analyses will be performed using RevMan 5.4. (3) Results: The results will be published as a peer-reviewed article. (4) Conclusions: The study will show which forms of intraepithelial neoplasia treatment change the cervicovaginal microbiome. Finding the best form of treatment by studying the cervicovaginal microbiome after various forms of treatment is essential. Patients would benefit not only from the treatment of the initial disease but also the management of dysbiosis, which might underlie other pathologies.
(1) 背景：微生物组由具有众多物理和化学特性的来自不同王国的微生物组成，其中乳杆菌属构成了健康宫颈和阴道微生物组的最高比例。微生态失调可能导致不良后果，例如细菌性阴道病、盆腔炎和妊娠并发症。宫颈阴道微生物组可能有助于持续性 HPV 感染的发展-宫颈癌的主要危险因素，并影响向恶性肿瘤的进展。目的是对目前关于宫颈上皮内瘤变治疗后微生物组变化的文献进行系统评价和荟萃分析。 (2) 方法：我们将搜索 PubMed、Scopus、Google Scholar 和 Embase 数据库，并追踪参考文献中的引文。将纳入本研究方案的研究类型包括：2000 年 1 月至 2021 年 5 月期间发表的随机和非随机对照研究、病例对照研究和队列研究。以下关键词将被使用：'微生物组'、'阴道微生物组'、'宫颈微生物组'、'宫颈肿瘤治疗'、'锥形切除术'、'电凝切除术'和'电外科治疗'。统计分析将使用 RevMan 5.4 进行。 (3) 结果：结果将作为同行评议文章发表。 (4) 结论：该研究将展示哪些形式的上皮内瘤变治疗会改变宫颈阴道微生物组。通过研究各种治疗形式后宫颈阴道微生物组，找到最佳的治疗形式至关重要。患者不仅将受益于初始疾病的治疗，还将受益于可能是其他病理基础的微生态失调的管理。
