Zhao Zhi, Peng Yijie, Yang Yuanyuan, Li Shuaiyu, Ling Jiang, Zhu Zhenyu, He Chenfeng
Zhengzhou Yihe Hospital, Postdoctoral Innovation Practice Base, Henan University, Zhengzhou, Henan, China.
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
J Cell Mol Med. 2025 Apr;29(7):e70097. doi: 10.1111/jcmm.70097.
While the oncogene ATP13A2 is reportedly involved in colorectal cancer, its role in cervical cancer (CC) has yet to be fully characterized. In this study, we investigated ATP13A2 as a potential prognostic biomarker of CC. To this end, we compared CC tissues with normal tissues to identify differentially expressed genes, identifying ATP13A2 as a potential marker of CC. Elevated ATP13A2 expression levels were identified in CC samples compared to noncancerous samples across various data sets, with further immunohistochemical validation. Functional enrichment analysis revealed that ATP13A2 plays an essential role in the CXCL12-activated CXCR4 signalling pathway and chemotaxis regulation, which may alter immune infiltration. Notably, increased ATP13A2 levels were associated with poor overall survival. Furthermore, multiple clinical characteristics were significantly associated with ATP13A2 expression. Additionally, tumour bacterial infiltration was assessed using weighted co-expression network analysis, revealing a relationship between ATP13A2 expression and bacteria in the CC tumour microenvironment. Our results suggest that ATP13A2 is a promising diagnostic and prognostic marker for CC. However, further large-scale studies are needed to fully elucidate the mechanisms underlying the involvement of ATP13A2 in CC.
虽然据报道致癌基因ATP13A2与结直肠癌有关，但其在宫颈癌（CC）中的作用尚未完全明确。在本研究中，我们将ATP13A2作为CC潜在的预后生物标志物进行了研究。为此，我们将CC组织与正常组织进行比较以鉴定差异表达基因，确定ATP13A2为CC的潜在标志物。在各种数据集中，与非癌样本相比，CC样本中ATP13A2表达水平升高，并通过进一步的免疫组织化学验证。功能富集分析表明，ATP13A2在CXCL12激活的CXCR4信号通路和趋化性调节中起重要作用，这可能会改变免疫浸润。值得注意的是，ATP13A2水平升高与总体生存率低相关。此外，多种临床特征与ATP13A2表达显著相关。另外，使用加权共表达网络分析评估肿瘤细菌浸润，揭示了CC肿瘤微环境中ATP13A2表达与细菌之间的关系。我们的结果表明，ATP13A2是CC有前景的诊断和预后标志物。然而，需要进一步的大规模研究来充分阐明ATP13A2参与CC的潜在机制。
