Lance J W, Anthony M
Arch Neurol. 1977 Jan;34(1):14-7. doi: 10.1001/archneur.1977.00500130034007.
Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months. Each agent was used sequentially in an overlapping group of 32 patients. Both agents have proven effective in the control of petit mal absences and myoclonic jerks, although some patients responded to one and not to the other. Clonazepam has given better results than valproate in temporal lobe and other partial (focal) epilepsies, while valproate has given better results in grand mal seizures and atonic attacks. Both preparations were more effective in patients with spike and wave paroxysms in their EEG recordings, the correlation being more conspicuous with valproate. Both medications appear to be safe and useful additions to anticonvulsant therapy.
在88例难治性癫痫患者中，60例接受氯硝西泮治疗长达三年，60例接受丙戊酸钠治疗长达18个月。每种药物在32例患者的重叠组中依次使用。两种药物在控制失神小发作和肌阵挛性抽搐方面均已证明有效，尽管有些患者对其中一种药物有反应而对另一种无反应。在颞叶癫痫和其他部分性（局灶性）癫痫中，氯硝西泮的效果优于丙戊酸钠，而丙戊酸钠在大发作和失张力发作方面效果更好。两种制剂对脑电图记录中有棘波和慢波阵发的患者更有效，丙戊酸钠的相关性更明显。两种药物似乎都是抗惊厥治疗中安全且有用的补充药物。
