Refractory shoulder injury related to vaccine administration: correlation with culture presence of .

BACKGROUND

Shoulder pain following intramuscular administration of vaccine is common. However, a small number of patients experience prolonged pain and dysfunction atypical to normal transient postvaccination shoulder pain. Shoulder Injury Related to Vaccine Administration (SIRVA) remains incompletely understood, whether a robust immune response to vaccine antigen or inappropriate injection technique with needle placement in synovial or bursal tissue, or some combination of the two. Symptoms overlap with those of () infection but the relationship between the two, if any, has not been evaluated.

METHODS

Clinical case files were reviewed for 3 cases of SIRVA with positive cultures for were reviewed. Presentation, treatment, and clinical outcomes were compared.

RESULTS

In all cases, patients were thin (body mass index < 23), females, who had high injection placement of a vaccine, all patients had positive magnetic resonance imaging findings of increased signal in the subacromial bursa, and/or greater tuberosity. All patients underwent arthroscopic débridement and culture harvest and cultures were positive for . A combination of oral and intravenous antibiotics was used, and all patients demonstrated clinical improvement from the preoperative state.

DISCUSSION

This case series presents 3 patients with refractory SIRVA who ultimately underwent arthroscopic irrigation and débridement with culture biopsy. Each case had culture results positive for and all responded, at least partially, to arthroscopic débridement and intravenous antibiotic therapy. The purpose of this manuscript is to raise awareness of potential coexistence of SIRVA and which may be of assistance to surgeons treating refractory cases of SIRVA.