Mircea Andrei Alexandru
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
UCLA Health Arrhythmia Center, Los Angeles, CA 90095, USA.
Discoveries (Craiova). 2023 Mar 31;11(1):e163. doi: 10.15190/d.2023.2. eCollection 2023 Jan-Mar.
Ventricular tachycardia (VT) and ventricular fibrillation (VF) are the most frequent causes of death in the first 24 hours after myocardial infarction. Previous studies showed that depleting TRPV1 receptors with resiniferatoxin (RTX) led to a reduced risk of VT and VF post-myocardial infarction. Therefore, the question of resiniferatoxin as a cardioprotector against myocardial infarction (MI)-induced VT and VF was raised. The RNA sequence data from 3 groups of pigs, each having 4 animals (4 controls, 4 myocardial infarction - MI, and 4 RTX + MI) was analyzed through the lens of differentially expressed genes. The differential expression comparison was conducted in two ways: MI versus Control and RTX+MI versus MI. The results showed the downregulation of deleterious genes involved in inflammation and future plaque instability in the RTX group compared with the MI group. In the case of some of the genes, these findings were reinforced by obtaining the same trends in the MI versus Control group. All in all, we propose further investigation of RTX as a prophylactic method against cardiovascular complications of MI.
室性心动过速（VT）和心室颤动（VF）是心肌梗死后24小时内最常见的死亡原因。先前的研究表明，用树脂毒素（RTX）耗尽瞬时受体电位香草酸亚型1（TRPV1）受体可降低心肌梗死后VT和VF的风险。因此，人们提出了树脂毒素作为预防心肌梗死（MI）诱发的VT和VF的心脏保护剂的问题。通过差异表达基因的视角分析了3组猪的RNA序列数据，每组有4只动物（4只对照、4只心肌梗死-MI和4只RTX+MI）。差异表达比较通过两种方式进行：MI组与对照组比较以及RTX+MI组与MI组比较。结果显示，与MI组相比，RTX组中参与炎症和未来斑块不稳定的有害基因下调。对于某些基因，在MI组与对照组中获得相同趋势进一步证实了这些发现。总而言之，我们建议进一步研究RTX作为预防MI心血管并发症的方法。
