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前置胎盘患者胎盘组织中的CXCL12/CXCR4/CXCR7轴

CXCL12/CXCR4/CXCR7 axis in placenta tissues of patients with placenta previa.

作者信息

Wu Xia, Wang Ying, Li Min

机构信息

Department of Obstetrics, Maternal and Child Health Hospital of Hubei Province, Wuhan 430070, Hubei, China.

出版信息

Open Life Sci. 2023 Aug 11;18(1):20220642. doi: 10.1515/biol-2022-0642. eCollection 2023.

DOI:10.1515/biol-2022-0642
PMID:37589008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10426756/
Abstract

CXCR4 and CXCR7 have been revealed to be receptors of CXCL12. This research was designed to probe the expression of chemokine CXCL12 and its receptors CXCR4 and CXCR7 in placental tissues of patients with placenta previa and the effect of CXCL12/CXCR4/CXCR7 axis on the biological functions of human trophoblast cells. CXCL12, CXCR4, and CXCR7 expression in placental tissue from patients with placenta previa and healthy puerperae was detected. CXCL12, CXCR4, and CXCR7 expression in human trophoblast cell lines (HTR8/SVneo cells) was assessed after suppression or overexpression of CXCL12, CXCR4, and CXCR7. The cell proliferative, invasive, and migratory capacities were also evaluated in HTR8/SVneo cells after suppression or overexpression of CXCL12, CXCR4, and CXCR7. CXCL12, CXCR4, and CXCR7 expression was elevated in placental tissues from patients with placenta previa. Downregulation of CXCL12, CXCR4, and CXCR7 could lead to decreased mRNA levels of CXCL12, CXCR4, and CXCR7 in HTR-8/SVneo cells, which was accompanied by diminished cell proliferative, migratory, and invasive capabilities. Overexpression of CXCL12, CXCR4, and CXCR7 genes presented an opposite tendency. CXCL12, CXCR4, and CXCR7 are highly expressed in placental tissues of patients with placenta previa and induce the biological activities of HTR8/SVneo cells.

摘要

CXCR4和CXCR7已被证实为CXCL12的受体。本研究旨在探讨趋化因子CXCL12及其受体CXCR4和CXCR7在前置胎盘患者胎盘组织中的表达情况，以及CXCL12/CXCR4/CXCR7轴对人滋养层细胞生物学功能的影响。检测前置胎盘患者及健康产妇胎盘组织中CXCL12、CXCR4和CXCR7的表达。在抑制或过表达CXCL12、CXCR4和CXCR7后，评估人滋养层细胞系（HTR8/SVneo细胞）中CXCL12、CXCR4和CXCR7的表达。在抑制或过表达CXCL12、CXCR4和CXCR7后，还评估了HTR8/SVneo细胞的增殖、侵袭和迁移能力。前置胎盘患者胎盘组织中CXCL12、CXCR4和CXCR7的表达升高。下调CXCL12、CXCR4和CXCR7可导致HTR-8/SVneo细胞中CXCL12、CXCR4和CXCR7的mRNA水平降低，同时细胞增殖、迁移和侵袭能力减弱。CXCL12、CXCR4和CXCR7基因的过表达呈现相反的趋势。CXCL12、CXCR4和CXCR7在前置胎盘患者胎盘组织中高表达，并诱导HTR8/SVneo细胞的生物学活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3431/10426756/c79bd5dca4f5/j_biol-2022-0642-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3431/10426756/a390a6c77f35/j_biol-2022-0642-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3431/10426756/8f96d7e48f5c/j_biol-2022-0642-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3431/10426756/69f0cadf040a/j_biol-2022-0642-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3431/10426756/c79bd5dca4f5/j_biol-2022-0642-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3431/10426756/a390a6c77f35/j_biol-2022-0642-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3431/10426756/8f96d7e48f5c/j_biol-2022-0642-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3431/10426756/69f0cadf040a/j_biol-2022-0642-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3431/10426756/c79bd5dca4f5/j_biol-2022-0642-fig004.jpg

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