Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
College of Korean Medicine, Gachon University, Seongnam 13120, Korea.
J Nat Prod. 2023 Aug 25;86(8):2031-2038. doi: 10.1021/acs.jnatprod.3c00468. Epub 2023 Aug 17.
Feature-based molecular networking analysis suggested the presence of naphthol tetramers in 047219, the same species but a different strain from one used previously for the discovery of naphthol trimers promoting adiponectin synthesis. The new tetramers were composed of 5-methoxy-4-naphthol, each of which was connected to one another in various positions. Targeted isolation afforded six previously unreported naphthol tetramers (-) together with 13 known polyketides (-) including naphthol monomers, dimers, and trimers. Structures of the isolated compounds were established by using NMR and mass spectroscopic analysis. Nodulisporin A (), nodulisporin B (), and 1,1',3',3″-ternaphthalene-5,5',5″-trimethoxy-4,4',4″-triol () demonstrated anti-inflammatory activities against NO production, but the new compounds were less active.
基于特征的分子网络分析表明，047219 中存在萘四聚体，该化合物与先前用于发现促进脂联素合成的萘三聚体的同种但不同菌株的物质相同。这些新的四聚体由 5-甲氧基-4-萘酚组成，每个萘酚以不同的位置彼此连接。通过靶向分离获得了六个以前未报道的萘四聚体（-）以及 13 种已知的聚酮类化合物（-），包括萘酚单体、二聚体和三聚体。通过 NMR 和质谱分析确定了分离化合物的结构。角鲨烯 A（）、角鲨烯 B（）和 1,1',3',3″-三萘-5,5',5″-三甲氧基-4,4',4″-三醇（）表现出对 NO 产生的抗炎活性，但新化合物的活性较低。
