血清 SOCS6 水平在糖尿病性视网膜病变中降低，且与疾病严重程度相关。

Serum levels of SOCS6 are decreased in diabetic retinopathy and are related to severity of the disease.

机构信息

Department of Ophthalmology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, China.

Department of Ophthalmology, Yihuang County People's Hospital, Fuzhou, China.

出版信息

Adv Clin Exp Med. 2023 Aug;32(8):873-880. doi: 10.17219/acem/159215.

DOI:10.17219/acem/159215

PMID:37589228

Abstract

BACKGROUND

Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus (DM). A recent in vitro study found that the suppressor of cytokine signaling 6 (SOCS6) plays a protective role in DR and DM. However, to date, no clinical studies have focused on the role of SOSC6 in DR development.

OBJECTIVES

The present study aimed to investigate the expression and clinical significance of serum SOCS6 in DR.

MATERIAL AND METHODS

A total of 159 DR patients were enrolled in the study. Additionally, 156 type 2 DM (T2DM) patients without DR were recruited as controls. Serum levels of SOCS6, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), vascular endothelial growth factor (VEGF), and angiopoietin-2 (ANG-2) were measured using enzyme-linked immunosorbent assay (ELISA). Demographic and clinical data were collected.

RESULTS

Age, the course of DM, systolic blood pressure (SBP), diastolic blood pressure (DBP), and the levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were significantly higher in proliferative DR (PDR) patients. Serum SOCS6 levels in PDR patients were remarkably lower than in non-PDR patients or non-DR T2DM patients. The Pearson's analysis showed that SOCS6 was negatively correlated with CRP, IL-6, TNF-α, IL-1β, VEGF, and ANG-2. The serum levels of CRP, IL-6, TNF-α, IL-1β, VEGF, and ANG-2 in the SOCS6 low expression group were significantly increased compared to patients with high SOCS6 levels. Receiver operating characteristic (ROC) curves showed that SOCS6 could be a potential diagnostic biomarker for DR. For logistic regression, 3 models were used. It was found that SOCS6, the course of DM, SBP and DBP in model 1, IL-1β and TNF-α in model 2, and VEGF and ANG-2 in model 3 were risk factors for DR.

CONCLUSIONS

The SOCS6 is decreased in DR patients and is related to severity and clinical outcomes, including inflammatory and angiogenic factors.

摘要

背景

糖尿病视网膜病变（DR）是糖尿病（DM）最常见的微血管并发症之一。最近的一项体外研究发现，细胞因子信号转导抑制因子 6（SOCS6）在 DR 和 DM 中发挥保护作用。然而，迄今为止，尚无临床研究关注 SOCS6 在 DR 发展中的作用。

目的

本研究旨在探讨 DR 患者血清 SOCS6 的表达及其临床意义。

材料与方法

共纳入 159 例 DR 患者，另纳入 156 例无 DR 的 2 型糖尿病（T2DM）患者作为对照。采用酶联免疫吸附试验（ELISA）法检测 SOCS6、C 反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、血管内皮生长因子（VEGF）和血管生成素-2（ANG-2）水平。收集患者的人口统计学和临床资料。

结果

与非增生性 DR（NPDR）患者或非 DR T2DM 患者相比，增生性 DR（PDR）患者的年龄、DM 病程、收缩压（SBP）、舒张压（DBP）以及低密度脂蛋白胆固醇（LDL-C）和总胆固醇（TC）水平均显著升高。PDR 患者血清 SOCS6 水平明显低于 NPDR 患者或非 DR T2DM 患者。Pearson 相关性分析显示，SOCS6 与 CRP、IL-6、TNF-α、IL-1β、VEGF 和 ANG-2 呈负相关。SOCS6 低表达组的 CRP、IL-6、TNF-α、IL-1β、VEGF 和 ANG-2 血清水平明显高于 SOCS6 高表达组。受试者工作特征（ROC）曲线显示，SOCS6 可能是 DR 的潜在诊断生物标志物。对于逻辑回归，使用了 3 个模型。结果发现，模型 1 中的 SOCS6、DM 病程、SBP 和 DBP，模型 2 中的 IL-1β和 TNF-α，以及模型 3 中的 VEGF 和 ANG-2 是 DR 的危险因素。