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电栅诱导的自愿性戒断减少雄性,但不减少雌性 iP 大鼠的觅酒行为。

Electric barrier-induced voluntary abstinence reduces alcohol seeking in male, but not female, iP rats.

机构信息

Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, University of Melbourne.

出版信息

Behav Neurosci. 2024 Feb;138(1):1-14. doi: 10.1037/bne0000566. Epub 2023 Aug 17.

Abstract

Maintaining abstinence and preventing relapse are key to the successful recovery from alcohol use disorder. There are two main ways individuals with alcohol use disorder abstain from alcohol use: forced (e.g., incarceration) and voluntary. Voluntary abstinence is often evoked due to the negative consequences associated with excessive alcohol consumption. This study investigated relapse-like behavior to alcohol seeking following acute, forced, and voluntary abstinence. Male rats had increased operant self-administration responding throughout training compared to females; however, females consumed greater amounts of alcohol in g/kg. Both male and female rats achieved voluntary abstinence, which was induced using an electric barrier on the operant chamber floor with alcohol readily available during this period. Interestingly, male rats that underwent voluntary abstinence displayed reduced alcohol seeking compared to males in the acute and forced abstinence groups. This difference in alcohol seeking behavior across abstinence groups was not observed in female rats. Quantification of neuronal activation (Fos protein) revealed numerous brain regions (e.g., ventral subiculum and lateral habenula) to be associated with the reduced reinstatement propensity seen in male rats that underwent voluntary abstinence. Additionally, hierarchical clustering found enhanced functional connectivity and coordination in the male voluntary abstinence group compared to the male forced abstinence group. Collectively, these data implicate a sexual dimorphism in the effect that voluntary abstinence, at least in the model employed here, has on relapse-like behavior. This maybe driven by reduced neuronal activation at a network level and enhanced functional connectivity and integration. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

摘要

维持戒断和防止复发是成功戒除酒精使用障碍的关键。患有酒精使用障碍的个体有两种主要的戒酒方式:强制(例如监禁)和自愿。自愿戒断通常是由于与过度饮酒相关的负面后果而引起的。本研究调查了急性、强制和自愿戒断后对酒精寻求的类似复发行为。雄性大鼠在整个训练过程中的操作性自我给药反应均高于雌性大鼠;然而,雌性大鼠每公斤体重摄入的酒精量更多。雄性和雌性大鼠都实现了自愿戒断,这是通过在操作室地板上的电屏障来诱导的,在此期间酒精可随时获得。有趣的是,与急性和强制戒断组的雄性大鼠相比,经历自愿戒断的雄性大鼠的酒精寻求减少。在雌性大鼠中没有观察到这种不同的戒断组之间的酒精寻求行为差异。神经元激活(Fos 蛋白)的定量分析显示,许多大脑区域(例如腹侧下托和外侧缰核)与经历自愿戒断的雄性大鼠中看到的复发性降低有关。此外,层次聚类发现,与雄性强制戒断组相比,雄性自愿戒断组的功能连接和协调增强。总的来说,这些数据表明,自愿戒断至少在本研究采用的模型中,对类似复发行为的影响存在性别二态性。这可能是由网络层面的神经元激活减少以及功能连接和整合增强驱动的。

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