Lipid Biochemistry Division, ICMR-National Institute of Nutrition, Jamai Osmania, Hyderabad, 500 007, Telangana, India.
Publication, Extension and Training Division, ICMR-National Institute of Nutrition, Jamai Osmania, Hyderabad, 500 007, Telangana, India.
Diabetes Metab Syndr. 2023 Sep;17(9):102844. doi: 10.1016/j.dsx.2023.102844. Epub 2023 Aug 9.
Consumption of coconut oil is implicated in cardiovascular disease risk. On the contrary, virgin coconut oil (VCO) is believed to offer better health benefits, however, the evidence to support such claims is lacking, particularly in humans. Therefore, this study aimed at assessing the impact of VCO in a balanced diet on HDL-C and some of the anthropometric and biochemical parameters associated with human cardiovascular health before and after the feeding experiment.
In a crossover observational study, apparently healthy non-obese male volunteers (n = 22) aged between 28 and 50years with a mean body weight of 67.5 kg were inducted into a two-arm controlled feeding experiment one after another for eight weeks with a six-week washout period. In the first arm, the diets were prepared with VCO, whereas peanut oil was used in the second arm (∼35g/day) as the control.
Compared to baseline, the consumption of VCO did not affect HDL-C and anthropometric measures at the end of the 8th week, whereas plasma total cholesterol (TC) and LDL-C levels (Means±standard error; 172 ± 5.6 mg/dL versus 186 ± 5.9 mg/dL and 113 ± 4.29 mg/dL versus 126 ± 4.17 mg/dL respectively) increased significantly. However, plasma triglycerides and some of the cardiovascular risk markers (namely, vascular cell-adhesion molecules, serum amyloid proteins and C-reactive protein) remained unaltered. Further, most of the changes in the VCO arm were comparable to the peanut oil regimen.
The consumption of VCO in a balanced diet displayed neutral effects on most parameters related to cardiovascular risk. However, the rise in TC and LDL-C must be tested in a larger sample size over longer periods.
椰子油的消费与心血管疾病风险有关。相反，初榨椰子油（VCO）被认为对健康有更好的益处，但缺乏支持这些说法的证据，特别是在人类中。因此，本研究旨在评估在均衡饮食中摄入 VCO 对高密度脂蛋白胆固醇（HDL-C）以及与人类心血管健康相关的一些人体测量学和生化参数的影响，在喂养实验前后进行评估。
在一项交叉观察性研究中，将年龄在 28 至 50 岁之间、平均体重为 67.5 公斤的非肥胖、貌似健康的男性志愿者（n=22）分为两组，连续进行为期八周的双盲对照喂养实验，其间有六周的洗脱期。在第一组中，饮食中使用 VCO，而在第二组中（约 35g/天）使用花生油作为对照。
与基线相比，在第八周结束时，VCO 的摄入并未影响 HDL-C 和人体测量学指标，而血浆总胆固醇（TC）和 LDL-C 水平（平均值±标准误差；172±5.6mg/dL 比 186±5.9mg/dL 和 113±4.29mg/dL 比 126±4.17mg/dL）显著升高。然而，血浆甘油三酯和一些心血管风险标志物（即血管细胞黏附分子、血清淀粉样蛋白和 C 反应蛋白）没有变化。此外，VCO 组的大多数变化与花生油方案相当。
在均衡饮食中摄入 VCO 对大多数与心血管风险相关的参数没有影响。然而，TC 和 LDL-C 的升高需要在更大的样本量和更长的时间内进行测试。
