Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Cardiac Primary Prevention Research Center (CPPRC), Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Nutr Metab Cardiovasc Dis. 2021 Mar 10;31(3):939-949. doi: 10.1016/j.numecd.2020.11.020. Epub 2020 Nov 27.
There is some promising evidence regarding the beneficial effect of coconut oil on cardiometabolic risk factors. This study aimed to assess the effects of virgin coconut oil (VCO) consumption on metabolic syndrome (MetS) components, as well as, asymmetric dimethylarginine (ADMA) in adults with MetS.
In this randomized controlled trial, 48 subjects, aged 20-50 years, with MetS were allocated into two groups; the intervention group was given 30 ml of VCO per day to substitute the same amounts of fat in their usual diet for four weeks. The control group was advised to follow their usual diet. VCO consumption significantly reduced serum levels of triglyceride (TG) (P = 0.001), very low-density lipoprotein (VLDL) (P = 0.001), and fasting blood sugar (FBS) (P = 0.015) compared to the control group. The levels of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) were significantly increased in the VCO group when compared to the control group (P = 0.001). Circulatory ADMA also increased in the VCO group compared to the control group (P = 0.003). No significant differences were observed in the LDL-C/HDL-C ratio, anthropometric parameters, and blood pressure measurements between the two groups at the end of the study (P > 0.05).
VCO consumption increased the values of HDL-C while reduced TG and FBS levels. Blood pressure and waist circumference did not change. However, levels of TC, LDL-C, and ADMA elevated by VCO consumption. Caution is warranted until the results of further studies become available to explain the long-term effects of VCO consumption.
IRCT20131125015536N11.
有一些有前景的证据表明椰子油对心血管代谢危险因素有益。本研究旨在评估初榨椰子油（VCO）对代谢综合征（MetS）患者代谢综合征成分以及不对称二甲基精氨酸（ADMA）的影响。
在这项随机对照试验中，48 名年龄在 20-50 岁之间的 MetS 患者被分为两组；干预组每天服用 30 毫升 VCO，以替代其日常饮食中的等量脂肪，持续四周。对照组被建议遵循他们的日常饮食。与对照组相比，VCO 消耗显著降低了血清甘油三酯（TG）（P=0.001）、极低密度脂蛋白（VLDL）（P=0.001）和空腹血糖（FBS）（P=0.015）水平。与对照组相比，高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和总胆固醇（TC）水平在 VCO 组显著升高（P=0.001）。与对照组相比，VCO 组的循环 ADMA 也增加（P=0.003）。在研究结束时，两组间 LDL-C/HDL-C 比值、人体测量参数和血压测量值无显著差异（P>0.05）。
VCO 消耗增加了 HDL-C 的水平，同时降低了 TG 和 FBS 水平。血压和腰围没有变化。然而，VCO 消耗使 TC、LDL-C 和 ADMA 的水平升高。在进一步的研究结果出来之前，需要谨慎解释 VCO 消耗的长期影响。
IRCT20131125015536N11。
