Department of Dermatology and Venereology, Centro Hospitalar Universitario de Lisboa Central, Lisbon, Portugal.
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361431.
Spiny keratoderma (SKD) is a rare palmoplantar keratoderma that presents with few to numerous millimetric hyperkeratotic projections on the palms and soles. It has been described with both hereditary and acquired variants. The acquired form, which presents in older adults, has been associated with a variety of systemic diseases and malignant conditions. In patients suspected of having acquired spiny keratoderma, an evaluation for malignant conditions may be warranted. Treatment with topical keratolytics or topical and oral retinoids is usually insufficient. Herein, we present the case of a 58-year-old man diagnosed with idiopathic SKD.
棘状角化病（SKD）是一种罕见的掌跖角化病，手掌和脚底会出现少量到大量毫米大小的角化过度突起。它既有遗传性也有获得性变异。获得性形式出现在老年人中，与多种系统性疾病和恶性疾病有关。对于疑似患有获得性棘状角化病的患者，可能需要进行恶性疾病的评估。局部角质松解剂或局部和口服维甲酸的治疗通常效果不佳。在此，我们报告了一例 58 岁男性特发性 SKD 的病例。
