Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S 4th Ring W Rd, Fengtai District, Beijing, 100070, China.
China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Cardiovasc Diabetol. 2023 Aug 17;22(1):210. doi: 10.1186/s12933-023-01936-y.
Atherogenic index of plasma (AIP) has been confirmed as a novel marker for myocardial infarction (MI), but few evidence on the long-term AIP and MI risk in general populations. We thus aimed to evaluate the relationships of cumulative exposure to AIP and its accumulation time course with the risk of MI.
A total of 54,440 participants were enrolled in the Kailuan study. Time-weighted cumulative AIP was calculated as the weighted sum of the mean AIP value for each time interval, then normalized by total exposure duration, the exposure duration was from 2006 to 2010. Duration of high AIP exposure was defined as the duration with high AIP and ranged from 0 to 6 years. The time course of AIP accumulation was categorized by the combination of time-weighted cumulative AIP < or ≥ median (- 0.12) and AIP slope.
After 11.05 years of follow-up, 766 incident MI cases were documented. After adjustment for potential confounders, higher risk of MI was observed in participants with the highest time-weighted cumulative AIP quartile (HR, 1.89; 95% CI 1.47-2.43), the longest exposure duration of high AIP (HR, 1.52; 95% CI 1.18-1.95), and those with high time-weighted cumulative AIP and negative slope (HR, 1.42; 95% CI 1.13-1.79).
Long-term cumulative exposure to AIP and the time course of AIP accumulation increased the risk of MI. High AIP earlier resulted in a greater risk increase than later in life with the same time-weighted cumulative AIP, emphasizing the importance of controlling atherogenic dyslipidemia early in life.
血浆致动脉粥样硬化指数（AIP）已被证实是心肌梗死（MI）的一种新型标志物，但关于一般人群中长期 AIP 和 MI 风险的证据很少。因此，我们旨在评估累积 AIP 暴露及其积累时间过程与 MI 风险之间的关系。
共有 54440 名参与者被纳入开滦研究。时间加权累积 AIP 计算为每个时间间隔的平均 AIP 值的加权和，然后通过总暴露时间进行归一化，暴露时间为 2006 年至 2010 年。高 AIP 暴露持续时间定义为高 AIP 持续时间，范围为 0 至 6 年。AIP 积累时间过程通过时间加权累积 AIP < 或 ≥ 中位数（-0.12）和 AIP 斜率的组合进行分类。
随访 11.05 年后，记录了 766 例新发 MI 病例。在调整了潜在混杂因素后，时间加权累积 AIP 四分位最高的参与者发生 MI 的风险更高（HR，1.89；95%CI 1.47-2.43），高 AIP 暴露持续时间最长（HR，1.52；95%CI 1.18-1.95），以及具有高时间加权累积 AIP 和负斜率的患者（HR，1.42；95%CI 1.13-1.79）。
长期累积暴露于 AIP 及其 AIP 积累时间过程增加了 MI 的风险。早期高 AIP 导致的风险增加大于一生中相同时间加权累积 AIP 导致的风险增加，强调了在生命早期控制致动脉粥样硬化血脂异常的重要性。
