Huang Pingping, Ren Gaocan, Wang Yifei, Liu Yicheng, Zhang Hongwei, Fu Shuangqing, Zhang Zhibo, Guo Lijun, Ma Xiaochang
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School, China Academy of Chinese Medical Sciences, Beijing, China.
Brain Behav. 2025 Aug;15(8):e70768. doi: 10.1002/brb3.70768.
Atherosclerosis is the primary cause of cerebrovascular disease, which in turn has substantial deleterious impacts on cognitive abilities. The atherogenic index of plasma (AIP), calculated as the logarithmic transformation of the ratio of triglycerides to high-density lipoprotein cholesterol (log[TG/HDL-C]), has emerged as a novel biomarker reflecting the balance between proatherogenic and antiatherogenic lipoproteins. Nevertheless, the association between AIP and cognitive function has not been examined in a large cohort. This study examined the relationship between AIP and cognitive performance in a nationally representative cohort of adult Americans.
A cross-sectional study was conducted using data from the 2011-2014 National Health and Nutrition Examination Survey (NHANES). The relationship between AIP and cognitive function was examined using several multivariate regression models with adjustment for arrays of potential confound factors. Fitted smoothed curves and threshold effect analysis were used to characterize possible nonlinear relationships.
The study population comprised 995 adults (mean age 63.01 ± 14.93 years; 51.86% female), with 49.65% identifying as non-Hispanic White, 9.15% as Mexican American, and 20.2% as non-Hispanic Black. Higher AIP was associated with greater risk of cognitive impairment. Negative correlations were detected between the AIP and both Animal Fluency Test (AFT) performance (β = -5.54, 95%CI: -9.26, -1.82, p < 0.05) and Digit Symbol Substitution Test (DSST) performance (β = -15.79, 95% CI: -26.32, -5.27, p < 0.05) after adjusting for multiple confounding variables.
Elevated AIP is associated with cognitive impairment in adult Americans.
动脉粥样硬化是脑血管疾病的主要病因，而脑血管疾病又会对认知能力产生重大的有害影响。血浆致动脉粥样硬化指数（AIP），计算为甘油三酯与高密度脂蛋白胆固醇比值的对数转换（log[TG/HDL-C]），已成为反映促动脉粥样硬化脂蛋白和抗动脉粥样硬化脂蛋白之间平衡的一种新型生物标志物。然而，尚未在大型队列中研究AIP与认知功能之间的关联。本研究在具有全国代表性的美国成年人群队列中，探讨了AIP与认知表现之间的关系。
采用2011 - 2014年国家健康与营养检查调查（NHANES）的数据进行横断面研究。使用多个多元回归模型，对一系列潜在混杂因素进行调整，以研究AIP与认知功能之间的关系。采用拟合平滑曲线和阈值效应分析来描述可能的非线性关系。
研究人群包括995名成年人（平均年龄63.01±14.93岁；51.86%为女性），其中49.65%为非西班牙裔白人，9.15%为墨西哥裔美国人，20.2%为非西班牙裔黑人。较高的AIP与认知障碍风险增加相关。在调整多个混杂变量后，检测到AIP与动物流畅性测试（AFT）表现（β = -5.54，95%CI：-9.26，-1.82，p < 0.05）和数字符号替换测试（DSST）表现（β = -15.79，95%CI：-26.32，-5.27，p < 0.05）之间均呈负相关。
AIP升高与美国成年人的认知障碍相关。
