Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China.
Ann Epidemiol. 2024 Feb;90:1-8. doi: 10.1016/j.annepidem.2023.11.002. Epub 2023 Nov 17.
The atherogenic index of plasma (AIP) has been shown to be related to cardiovascular disease risk, but evidence on the longitudinal pattern of AIP during follow-up is limited. We aimed to explore the associations of baseline and long-term AIP with the risk of myocardial infarction (MI).
We included 98,861 participants in the Kailuan Study who were free of MI at baseline. AIP was calculated as log (triglyceride/high-density lipoprotein cholesterol). Long-term AIP included the long-term mean AIP (mean AIP from baseline to the first occurrence of MI or the end of follow-up) and number of visits with high AIP (above the cutoff value at the first three visits). The baseline and updated mean AIP were in operationalized as quartiles. Cox proportional hazard models were used to determine the associations between AIP and risk of MI. We excluding all deaths during the follow-up visits in the sensitivity analysis.
During a median follow-up of 12.80 years, 1804 participants developed MI. Compared with quartile 1, the adjusted hazard ratios in baseline and updated mean AIP quartile 4 were 1.63 (95% CI, 1.41-1.88) and 1.59 (95% CI, 1.37-1.83), respectively. Compared with participants who did not have a high AIP, the HR among individuals with AIP elevated by three times was 1.94 (95% CI,1.55-2.45). The sensitivity analysis showed similar associations.
Elevated levels of both baseline and long-term AIP increased the risk of MI.
血浆致动脉粥样硬化指数（AIP）已被证明与心血管疾病风险相关，但关于随访期间 AIP 纵向变化模式的证据有限。我们旨在探讨基线和长期 AIP 与心肌梗死（MI）风险的相关性。
我们纳入了 98861 名在基线时无 MI 的 Kailuan 研究参与者。AIP 计算为 log（甘油三酯/高密度脂蛋白胆固醇）。长期 AIP 包括长期平均 AIP（从基线到首次发生 MI 或随访结束时的平均 AIP）和高 AIP 就诊次数（前三次就诊时的截止值以上）。基线和更新的平均 AIP 被操作化为四分位数。使用 Cox 比例风险模型确定 AIP 与 MI 风险之间的关联。在敏感性分析中，我们排除了随访期间所有死亡。
在中位数为 12.80 年的随访期间，1804 名参与者发生了 MI。与四分位 1 相比，基线和更新的平均 AIP 四分位 4 的调整后的危险比分别为 1.63（95%CI，1.41-1.88）和 1.59（95%CI，1.37-1.83）。与 AIP 不升高的参与者相比，AIP 升高三倍的个体的 HR 为 1.94（95%CI，1.55-2.45）。敏感性分析显示出类似的关联。
基线和长期 AIP 水平升高均增加了 MI 的风险。
