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从鼻孔到伤口:探索葡萄球菌手术部位感染的机制及其对感染预防的意义

"From Nares to Wound: Exploring the mechanisms for Staphylococcal surgical site infections, implications for infection prevention".

作者信息

Troeman Darren P R, Kluytmans Jan A J W

机构信息

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

出版信息

Antimicrob Steward Healthc Epidemiol. 2023 Jul 26;3(1):e130. doi: 10.1017/ash.2023.197. eCollection 2023.

DOI:10.1017/ash.2023.197
PMID:37592968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10428146/
Abstract

Surgical site infections (SSIs) are important healthcare-associated infections, leading to increased morbidity and mortality, healthcare costs, and prolonged hospital stays. is an important and common microbial cause of SSI. Nasal carriage of has been shown to be an important determinant for the development of SSI, and interventions aimed at eradicating preoperative nasal carriage are associated with a reduced risk of infection. Yet, it is not entirely clear how the nasally residing causes SSI at distant body sites. In this commentary, we describe our view on how can be transported from the nares to the incision site during surgery. In addition, we shed light on the implications of our view for infection prevention research.

摘要

手术部位感染(SSIs)是重要的医疗相关感染,会导致发病率和死亡率上升、医疗成本增加以及住院时间延长。[微生物名称]是手术部位感染的一种重要且常见的微生物病因。已证明鼻腔携带[微生物名称]是手术部位感染发生的一个重要决定因素,旨在根除术前鼻腔携带的干预措施与感染风险降低相关。然而,尚不完全清楚鼻腔内的[微生物名称]如何在远处身体部位引发手术部位感染。在这篇评论中,我们阐述了关于[微生物名称]在手术过程中如何从鼻孔传播至切口部位的观点。此外,我们还阐明了该观点对感染预防研究的意义。