Askaripour Majid, Najafipour Hamid, Saberi Shadan, Dabiri Shahriar, Iranpour Maryam, Etminan Abbas, Nematbakhsh Mehdi
Department of Physiology, School of Medicine, Bam University of Medical Sciences, Bam, I.R. Iran.
Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, I.R. Iran.
Res Pharm Sci. 2023 Mar 10;18(3):262-269. doi: 10.4103/1735-5362.371582. eCollection 2023 May-Jun.
Renal ischemia/reperfusion (IR) injury is a pathologic phenomenon that caused to increase risk of mortality. The main objective of this study was to investigate the effect of sodium hydrogen sulfide (NaHS) on renal IR injury in male and female rats.
Fifty-eight male and female rats were randomized into 4 groups of control, sham, IR, and IR + NaHS. The IR was performed by 45 min of ischemia by vessel clamping followed by 24 h reperfusion. The NaHS (100 µmol/kg) treatment was applied 10 min prior to IR. Finally, after 24 h of reperfusion, the measurements were performed.
FINDINGS/RESULTS: The serum levels of blood urea nitrogen, creatinine, tissue level of malondialdehyde, and kidney tissue damage score (KTDS) were increased by IR. Urine volume, creatinine, and urea clearances decreased by IR. NaHS administration improved some parameters in males but exacerbated KTDS and serum markers related to renal function.
Our data demonstrated that NaHS didn't protect female rats against renal IR injury. In males, it has null effects or just a few protective effects antioxidant activity.
肾缺血/再灌注（IR）损伤是一种导致死亡风险增加的病理现象。本研究的主要目的是探讨硫化氢钠（NaHS）对雄性和雌性大鼠肾IR损伤的影响。
58只雄性和雌性大鼠被随机分为对照组、假手术组、IR组和IR + NaHS组。通过血管夹闭45分钟缺血，随后再灌注24小时来进行IR。在IR前10分钟给予NaHS（100 µmol/kg）治疗。最后，在再灌注24小时后进行测量。
IR导致血清尿素氮、肌酐水平、丙二醛组织水平和肾组织损伤评分（KTDS）升高。IR使尿量、肌酐和尿素清除率降低。给予NaHS改善了雄性大鼠的一些参数，但加剧了KTDS和与肾功能相关的血清标志物。
我们的数据表明，NaHS不能保护雌性大鼠免受肾IR损伤。在雄性大鼠中，它没有作用或仅有一些抗氧化活性的保护作用。
