Patel Chirag, Thakur Khushboo, Shagond Lalita, Acharya Sanjeev, Ranch Ketan, Boddu Sai Hs
Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, India-380009, India.
Department of Pharmacology, SSR College of Pharmacy, Silvassa, Dadra and Nagar Haveli, India-396230, India.
Res Pharm Sci. 2023 Mar 10;18(3):303-316. doi: 10.4103/1735-5362.371586. eCollection 2023 May-Jun.
Huntington's disease (HD) is a neurodegenerative disease characterized by neuronal death in the striatum. Asiatic acid is an active component of (Dipterocarpaceae) plants with neuroprotective activity and is considered an acceptable therapeutic candidate for different neurodegenerative diseases. In the present study, the beneficial pharmacological action of resin extract (SRRE) was assessed in 3-nitropropionic acid (3-NP)-induced HD in rats.
The neuroprotective effect of SRRE (285.7 and 666.7 mg/kg, p.o., 14 days) was studied in 3-NP (10 mg/kg)-induced rats by measuring body weight, behavioral parameters including neurological scoring, motor coordination, spatial memory, and depression-like behavior, neuro-biochemical parameters (gamma-aminobutyric acid and acetylcholinesterase), and oxidative stress parameter in the brain. Histopathology of the rat's brain was also studied.
FINDINGS/RESULTS: SRRE treatment (285.7 mg/kg and 666.7 mg/kg) substantially restored body weight, motor coordination, and mitochondrial enzyme complex I function and improved memory impairment as compared to 3-NP-treated rats. Furthermore, SRRE treatment significantly restored the antioxidant enzyme activity in brain tissue and ameliorated the histopathological changes induced by 3-NP.
The neuroprotective effect of SRRE on 3-NP-induced HD in rats was mediated by a reduction in oxidative stress which may favor the usefulness of in HD.
亨廷顿舞蹈症（HD）是一种神经退行性疾病，其特征为纹状体中的神经元死亡。齐墩果酸是龙脑香科植物的一种具有神经保护活性的活性成分，被认为是治疗不同神经退行性疾病的一个可接受的候选药物。在本研究中，评估了龙脑香树脂提取物（SRRE）对3-硝基丙酸（3-NP）诱导的大鼠HD的有益药理作用。
通过测量体重、行为参数（包括神经评分、运动协调性、空间记忆和抑郁样行为）、神经生化参数（γ-氨基丁酸和乙酰胆碱酯酶）以及大脑中的氧化应激参数，研究了SRRE（285.7和666.7毫克/千克，口服，14天）对3-NP（10毫克/千克）诱导的大鼠的神经保护作用。还研究了大鼠大脑的组织病理学。
与3-NP处理的大鼠相比，SRRE处理（285.7毫克/千克和666.7毫克/千克）显著恢复了体重、运动协调性和线粒体酶复合物I的功能，并改善了记忆障碍。此外，SRRE处理显著恢复了脑组织中的抗氧化酶活性，并改善了3-NP诱导的组织病理学变化。
SRRE对3-NP诱导的大鼠HD的神经保护作用是通过降低氧化应激介导的，这可能有利于其在HD中的应用。
