Kratiras Zisis, Kaltsas Aris, Koufopoulos Nektarios, Adamos Konstantinos, Chrisofos Michail
Third Department of Urology, School of Medicine, Attikon University Hospital, University of Athens, Athens, GRC.
Department of Urology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GRC.
Cureus. 2023 Jul 17;15(7):e41998. doi: 10.7759/cureus.41998. eCollection 2023 Jul.
Paraganglioma of the urinary bladder is an exceptionally rare tumor. It originates from chromaffin cells, which are responsible for producing catecholamines. We report a unique case of a 74-year-old woman diagnosed with nonfunctional bladder paraganglioma, who presented with macroscopic hematuria and right-sided renal colic but lacked the usual symptoms associated with catecholamine excess. This case highlights the diagnostic challenges of nonfunctional variants of paraganglioma due to their histological similarity to urothelial carcinomas. It underscores the importance of a thorough histological examination and the need for a multidisciplinary approach to establish a diagnosis and determine the optimal treatment strategy. Our case contributes to the sparse literature on this rare condition, and it aims to enhance clinicians' awareness and understanding of urinary bladder paragangliomas.
膀胱副神经节瘤是一种极为罕见的肿瘤。它起源于负责产生儿茶酚胺的嗜铬细胞。我们报告了一例独特病例，一名74岁女性被诊断为无功能膀胱副神经节瘤，表现为肉眼血尿和右侧肾绞痛，但缺乏与儿茶酚胺过量相关的常见症状。该病例凸显了副神经节瘤无功能变体因其组织学与尿路上皮癌相似而带来的诊断挑战。它强调了全面组织学检查的重要性以及采用多学科方法来确立诊断和确定最佳治疗策略的必要性。我们的病例丰富了关于这种罕见病症的稀少文献，并旨在提高临床医生对膀胱副神经节瘤的认识和理解。
