Gebregziabher Knife Tsehaye, Kazali Bedri Ahmed, Abrar Fadil Nuredin, Gebremariam Awash Solomon, Hamza Abdurrhman Kedir, Alemu Tsiyon Ngusie
Addis Ababa University, School of Medicine, Department of Surgery, Urology Unit, Ethiopia.
Addis Ababa University, School of Medicine, Department of Surgery, Urology Unit, Ethiopia.
Int J Surg Case Rep. 2025 Apr;129:111169. doi: 10.1016/j.ijscr.2025.111169. Epub 2025 Mar 17.
Non-functioning paraganglioma of the bladder is extremely rare disease. It is important to know the presence of paraganglioma of the bladder as the early and correct diagnosis affects the management and prognosis of the patient. Pathologists may misinterpret it as part of cystitis cystica/glandularis or nested variant urothelial carcinoma, or secondary bladder involvement by prostatic adenocarcinoma. This report will contribute to the existing literature and provide valuable insights into the clinical characteristics and treatment options for this rare tumor.
35 years old female patient presented after incidental finding of bladder mass on abdominal ultrasound during routine antenatal follow up. Cystoscope showed 2 × 2 cm single solid bladder mass. Microscopic examination was suggestive of neuroendocrine tumor with paragangliom as a differential diagnosis. Imminohistochemical studies showed positive for synaptophysin, S100, GATA-3 and negative for panCK. The patient was managed with partial cystectomy.
Non-functioning paragnaglioma of the urinary bladder is a rare extra-adrenal pheochromocystoma. The diagnosis is usually challenging and it may mimic urothelial carcinoma. Histopathology and immunohistochemistry are almost always confirmatory.
Urinary bladder paraganglioma may mimic nested variant of the bladder tumor. High clinical suspicion is important. Confirmation is with histopathology and immunohistochemistry. Partial cystectomy is treatment of choice.
膀胱无功能副神经节瘤是一种极为罕见的疾病。了解膀胱副神经节瘤的存在很重要，因为早期正确诊断会影响患者的治疗和预后。病理学家可能会将其误诊为囊性膀胱炎/腺性膀胱炎的一部分、巢状变异型尿路上皮癌或前列腺腺癌继发膀胱受累。本报告将为现有文献做出贡献，并为这种罕见肿瘤的临床特征和治疗选择提供有价值的见解。
一名35岁女性患者在常规产前检查期间腹部超声偶然发现膀胱肿块后前来就诊。膀胱镜检查显示一个2×2厘米的单个实性膀胱肿块。显微镜检查提示为神经内分泌肿瘤，副神经节瘤为鉴别诊断。免疫组织化学研究显示突触素、S100、GATA-3呈阳性，泛细胞角蛋白呈阴性。该患者接受了膀胱部分切除术。
膀胱无功能副神经节瘤是一种罕见的肾上腺外嗜铬细胞瘤。诊断通常具有挑战性，可能会模仿尿路上皮癌。组织病理学和免疫组织化学几乎总是具有确诊意义。
膀胱副神经节瘤可能模仿膀胱肿瘤的巢状变异型。高度的临床怀疑很重要。通过组织病理学和免疫组织化学进行确诊。膀胱部分切除术是首选治疗方法。
