School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
School of Nursing, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Endocrinol (Lausanne). 2023 Aug 1;14:1203677. doi: 10.3389/fendo.2023.1203677. eCollection 2023.
Diabetic peripheral neuropathy (DPN) is the main cause of disability in diabetes patients but the efficacy of available drugs is poor. Moxibustion is an adjunctive treatment for DPN that can reduce symptoms. The peak value of the far infrared wavelength of 10.6 μm laser moxibustion is close to the infrared radiation spectrum of traditional moxibustion. Its effect is similar to that of moxibustion and does not cause pain, infection or produce irritating smoke. Twenty-four male SD rats were divided into control (Con), DPN, laser moxibustion (LM), and pyrrolidine dithiocarbamate (PDTC) groups (n=6/group). The DPN, LM and PDTC group rats were intraperitoneally injected with 1% streptozotocin (STZ) to induce a model of DPN. LM group rats were irradiated with a laser at bilateral ST36 acupoints for 15 min, once every other day, for 14 days. PDTC group rats were intraperitoneally injected with PDTC once a day. Body weight, blood glucose, and paw withdrawal mechanical threshold (PWMT) were measured and laser speckle imaging (LSI) performed before and after modeling and at 1 and 2 weeks after intervention. Two weeks after intervention, changes in serum interleukin 1β (IL1β), interleukin 6 (IL6), tumor necrosis factor α (TNFα) and nerve growth factor (NGF) were analyzed, and the abundance of NF-κB and IκB-α proteins and levels of NF-κB and IκB-α mRNAs in the sciatic nerve were observed. The results showed that 10.6 μm laser moxibustion can relieve pain, improve microcirculation, and alleviate inflammation in DPN rats, possibly via the NF-κB inflammatory pathway.
糖尿病周围神经病变（DPN）是糖尿病患者致残的主要原因，但现有药物的疗效不佳。艾灸是 DPN 的辅助治疗方法，可以减轻症状。10.6μm 激光灸的远红外波长峰值接近传统艾灸的红外辐射光谱。其作用与艾灸相似，不会引起疼痛、感染或产生刺激性烟雾。将 24 只雄性 SD 大鼠分为对照组（Con）、DPN 组、激光灸（LM）组和吡咯烷二硫代氨基甲酸盐（PDTC）组（每组 6 只）。DPN 组、LM 组和 PDTC 组大鼠腹腔注射 1%链脲佐菌素（STZ）诱导 DPN 模型。LM 组大鼠在双侧 ST36 穴位照射激光 15 分钟，隔日一次，共 14 天。PDTC 组大鼠每天腹腔注射 PDTC。在建模前、建模后及干预后 1 周和 2 周测量体重、血糖和足底机械阈值（PWMT），并进行激光散斑成像（LSI）。干预 2 周后，分析血清白细胞介素 1β（IL1β）、白细胞介素 6（IL6）、肿瘤坏死因子 α（TNFα）和神经生长因子（NGF）的变化，观察坐骨神经中 NF-κB 和 IκB-α 蛋白的丰度以及 NF-κB 和 IκB-α mRNA 的水平。结果表明，10.6μm 激光灸可以缓解疼痛，改善微循环，减轻 DPN 大鼠的炎症，可能通过 NF-κB 炎症途径。
