Nuti D, Ciacci G, Giannini F, Rossi A, Federico A
Ital J Neurol Sci. 1986 Aug;7(4):453-9. doi: 10.1007/BF02283025.
We report two cases of non periodic alternating nystagmus, one of vascular origin (ischemia of the vertebrobasilar territory) and a second of traumatic origin (whiplash injury) with otoneurological signs, typical of lesions in posterior cranial fossa and in particular of vestibulum-cerebellum and brainstem: gaze paretic nystagmus, rebound nystagmus, saccadic dysmetria, vestibular hyperreflexia and impaired visual suppression test. In one case it was possible to give baclofen therapy, which yielded positive results. Suspension of drug administration resulted in the worsening of clinical signs. The mechanism of action of the drug will be discussed.
我们报告了两例非周期性交替性眼球震颤病例，一例为血管源性（椎基底动脉区域缺血），另一例为创伤性（挥鞭样损伤），伴有耳神经学体征，典型表现为后颅窝病变，尤其是前庭小脑和脑干病变：凝视性麻痹性眼球震颤、反弹性眼球震颤、眼球运动失调、前庭反射亢进以及视觉抑制试验受损。在其中一例中，给予巴氯芬治疗取得了阳性结果。停药后临床体征恶化。将讨论该药物的作用机制。
