Department of Neurology and Neuro-ophthalmology, Michigan State University, East Lansing, Michigan, USA.
Curr Opin Ophthalmol. 2012 Nov;23(6):510-6. doi: 10.1097/ICU.0b013e328358ba6e.
This article synthesises recent findings and addresses relevant anatomy, pathophysiologic considerations, and current treatment options for common forms of acquired nystagmus including vestibular and gaze holding dysfunction.
Some forms of nystagmus have relatively specific treatments, such as baclofen for periodic alternating nystagmus, and repositioning for benign paroxysmal positional vertigo. Recent studies have brought changes to many of the treatments of nystagmus variants. Additionally, other recent advances in nystagmus treatment, like the usage of 4-aminopyridine, have added potent medications to the physician's armamentarium.
Nystagmus is a commonly encountered entity in clinical practice. However, evidence supported treatments are scarce. Medical treatment of nystagmus is difficult, with often limited and variable response to pharmacologic therapies. This mandates a continued re-evaluation of patients and creation of an individualized approach to this common clinical problem.
本文综合了最近的研究结果，并针对常见获得性眼球震颤的相关解剖学、病理生理学考虑因素和当前治疗选择进行了讨论，包括前庭性和凝视性眼球震颤功能障碍。
某些形式的眼球震颤具有相对特定的治疗方法，例如巴氯芬治疗周期性交替性眼球震颤，变位治疗良性阵发性位置性眩晕。最近的研究改变了许多眼球震颤变异的治疗方法。此外，眼球震颤治疗的其他最新进展，如 4-氨基吡啶的使用，为医生的治疗手段增添了有效的药物。
眼球震颤在临床实践中很常见，但支持治疗的证据很少。眼球震颤的药物治疗很困难，药物治疗反应通常有限且多变。这就需要不断重新评估患者，并针对这一常见临床问题制定个体化的治疗方法。
