Division of Rheumatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Rheumatology (Oxford). 2023 Dec 1;62(12):3804-3810. doi: 10.1093/rheumatology/kead416.
Interleukin-6 (IL-6) is one of the cytokines implicated in murine and human SLE. Only a few small studies have investigated IL-6 inhibition in human SLE. Currently, there are no studies registered in clinicaltrials.gov to assess the IL-6 targeted therapy in SLE, yet its role in the future remains to be defined. This narrative review analyses these and potential areas of future studies with IL-6 targeted therapy in SLE.
白细胞介素-6（IL-6）是参与小鼠和人类系统性红斑狼疮（SLE）的细胞因子之一。只有少数小型研究调查了人类 SLE 中 IL-6 抑制的情况。目前，clinicaltrials.gov 上没有登记评估 SLE 中 IL-6 靶向治疗的研究，但它在未来的作用仍有待确定。本叙述性综述分析了这些研究以及 SLE 中 IL-6 靶向治疗的潜在未来研究领域。
