Orsolini P, Milani M R, Velgi C
Arzneimittelforschung. 1979;29(2):179-81.
The paper presents the results of a study on the action of five non-steroidal antiinflammatory agents (phenylbutazone, indometacin, acetylsalicylic acid, niflumic and flufenamic acids) on two biological activities which are dependent on complement activation: opsonization of bacteria and membrane damage, the latter evaluated both with the classic immunohemolytic system and with a bactericidal assay. The three biological assays differ for complement sequences involved. Flufenamic and niflumic acids showed high inhibitory activity in the lytic assays. Human complement was more sensitive to inhibition than guinea-pig complement. Phagocytic test confirmed the inhibitory activity of flufenamic acid on complement dependent opsonization.
本文介绍了一项关于五种非甾体抗炎药（保泰松、吲哚美辛、乙酰水杨酸、尼氟酸和氟芬那酸）对两种依赖补体激活的生物学活性作用的研究结果：细菌调理作用和膜损伤，后者通过经典免疫溶血系统和杀菌试验进行评估。三种生物学试验因涉及的补体序列不同而有所差异。氟芬那酸和尼氟酸在溶血试验中显示出高抑制活性。人补体比豚鼠补体对抑制更敏感。吞噬试验证实了氟芬那酸对补体依赖性调理作用的抑制活性。
