West L, McIntosh N, Gendler S, Seymour C, Wisdom C
Int J Radiat Oncol Biol Phys. 1986 Aug;12(8):1319-23. doi: 10.1016/0360-3016(86)90163-x.
Rats were injected with a fractionated 50 ml/kg dose of Fluosol-DA 20% with and without exposure to 100% oxygen. Animals were killed at 24, 43, 92, and 183 days post-treatment and samples taken for hematological, hepatic enzyme, histological, and perfluorochemical analyses. There were no significant differences in hemograms or hepatic enzyme findings between treatment and control groups. Differences in organ weights and histology were a result of perfluorochemical (PFC) accumulation in the tissues of treated animals. All changes were reversible. There were no effects from breathing high oxygen levels in either treatment or control animals.
给大鼠注射分剂量为50毫升/千克的20%全氟三丙胺乳剂，部分大鼠同时暴露于100%氧气环境。在治疗后24天、43天、92天和183天处死动物，并采集样本进行血液学、肝酶、组织学和全氟化合物分析。治疗组和对照组之间的血常规或肝酶检查结果无显著差异。器官重量和组织学的差异是由于全氟化合物（PFC）在接受治疗动物的组织中蓄积所致。所有变化都是可逆的。无论是治疗组还是对照组动物，呼吸高氧水平均无影响。
