从绒毛山麻杆的嫩枝和叶子中分离得到的生物活性二萜。

Bioactive diterpenoids isolated from the twigs and leaves of Casearia velutina.

机构信息

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming 650500, People's Republic of China.

出版信息

Fitoterapia. 2023 Dec;171:105654. doi: 10.1016/j.fitote.2023.105654. Epub 2023 Aug 16.

DOI:10.1016/j.fitote.2023.105654

PMID:37595644

Abstract

Nine previously undescribed clerodane-type diterpenoids (1-9), named caseabalanspenes A-I, along with six know compounds (10-15), were isolated from the twigs and leaves of Casearia velutina. Spectroscopic data (1D and 2D NMR) analysis permitted the definition of their structures and then determination of the molecular formula of the compound by high resolution mass spectrometry (HR-ESI-MS). It is worth noting that compound 7 contains N- heterocycle. Compounds 1-8 were tested the anti-inflammasome activity, and compound 3 exhibited potent activity and decreased LDH level in a dose-dependent manner, with IC values of 2.90 μM.

摘要

从绒毛山胡椒的嫩枝和叶片中分离得到了 9 个以前未描述的 clerodane 型二萜（1-9），命名为 caseabalanspenes A-I，以及 6 个已知化合物（10-15）。通过光谱数据分析（1D 和 2D NMR）确定了它们的结构，然后通过高分辨质谱（HR-ESI-MS）确定了化合物的分子公式。值得注意的是，化合物 7 含有 N-杂环。测试了化合物 1-8 的抗炎症小体活性，化合物 3 表现出较强的活性，并呈剂量依赖性降低 LDH 水平，IC 值为 2.90 μM。