Zhu Wenjun, Yuan Naijun, Wan Chunmiao, Huang Minyi, Fang Shaoyi, Chen Man, Chen Jianbei, Ma Qingyu, Chen Jiaxu
Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, PR China.
Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, PR China; Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong 518020, PR China; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, PR China.
J Affect Disord. 2023 Nov 1;340:626-638. doi: 10.1016/j.jad.2023.08.069. Epub 2023 Aug 17.
Bipolar disorder (BD) is a severe psychiatric illness with an increasing prevalence worldwide. Although the pathological mechanism of and pharmacological interventions for BD have been extensively investigated in preclinical and clinical studies, a scientometric analysis of the developmental trends, interdisciplinary frontiers, and research hotspots in this field has not yet been conducted. Therefore, we performed a comprehensive scientometric review of 55,358 published studies on BD over the past two decades (2002-2021) to identify the most frequently used keywords and explore research hotspots and trajectories. The present findings revealed the main distribution, knowledge structure, topic evolution, and emerging topics of BD research. Analysing the risk factors, pathogenesis, key brain regions, comorbid conditions, and treatment strategies for BD contributed to understanding of the aetiology, progression, and treatment of this disorder. These findings provided substantial support for continued research in this area.
双相情感障碍（BD）是一种严重的精神疾病，在全球范围内的患病率呈上升趋势。尽管在临床前和临床研究中对双相情感障碍的病理机制和药物干预进行了广泛研究，但尚未对该领域的发展趋势、跨学科前沿和研究热点进行科学计量分析。因此，我们对过去二十年（2002年至2021年）发表的55358项关于双相情感障碍的研究进行了全面的科学计量综述，以确定最常用的关键词，并探索研究热点和轨迹。目前的研究结果揭示了双相情感障碍研究的主要分布、知识结构、主题演变和新兴主题。分析双相情感障碍的危险因素、发病机制、关键脑区、共病情况和治疗策略，有助于理解该疾病的病因、进展和治疗。这些发现为该领域的持续研究提供了有力支持。
