非选择性（普萘洛尔）和心脏选择性（美托洛尔）β-肾上腺素能受体阻滞剂在静息和运动时的降压作用。
Antihypertensive effect of a non-selective (propranolol) and a cardioselective (metoprolol) beta-adrenoceptor blocking agent at rest and during exercise.
作者信息
Clausen N, Damsgaard T, Mellemgaard K
出版信息
Br J Clin Pharmacol. 1979 Apr;7(4):379-83. doi: 10.1111/j.1365-2125.1979.tb00949.x.
Abstract
1 The antihypertensive effects at rest and during physical exercise of the non-selective beta-adrenoceptor blocker propranolol and the cardioselective beta-adrenoceptor blocker metoprolol were compared in a double-blind cross-over study. 2 Eighteen patients with mild hypertension entered the trial. One patient was withdrawn from the study due to side effects on both drugs. 3 The two beta-adrenoceptor blockers were compared using doses earlier shown to have the same beta-adrenoceptor blocking potency, as measured by their effect on exercise tachycardia in healthy men. 4 Arterial blood pressure was reduced to the same extent by propranolol and metoprolol at rest as well as during submaximal work. 5 It is concluded that the antihypertensive effect of beta-adrenoceptor blockers is mainly mediated through blockade of the beta 1-adrenoceptors.
摘要
- 在一项双盲交叉研究中，比较了非选择性β肾上腺素能受体阻滞剂普萘洛尔和心脏选择性β肾上腺素能受体阻滞剂美托洛尔在静息和体育锻炼期间的降压效果。2. 18例轻度高血压患者进入试验。1例患者因对两种药物均有副作用而退出研究。3. 使用先前显示具有相同β肾上腺素能受体阻断效力的剂量比较这两种β肾上腺素能受体阻滞剂，该效力通过它们对健康男性运动性心动过速的影响来衡量。4. 普萘洛尔和美托洛尔在静息时以及次最大运动量期间均将动脉血压降低到相同程度。5. 得出结论，β肾上腺素能受体阻滞剂的降压作用主要通过阻断β1肾上腺素能受体介导。
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本文引用的文献
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Am J Cardiol. 1972 May;29(5):633-40. doi: 10.1016/0002-9149(72)90164-6.
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Int J Clin Pharmacol. 1974 Oct;10(3):206-11.
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Initial clinical experience with I.C.I. 66.082, a new beta-adrenergic blocking agent, in hypertension.
Acta Med Scand. 1973 Dec;194(6):549-50. doi: 10.1111/j.0954-6820.1973.tb19489.x.
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