β-肾上腺素能受体阻滞剂与糖尿病患者的血糖控制
Beta-adrenoceptor-blocking drugs and blood sugar control in diabetes mellitus.
作者信息
Wright A D, Barber S G, Kendall M J, Poole P H
出版信息
Br Med J. 1979 Jan 20;1(6157):159-61. doi: 10.1136/bmj.1.6157.159.
Abstract
The effects on diabetic control of the relative cardioselective beta-blocker metoprolol and the non-selective drug propranolol were compared in 20 hypertensive diabetic patients receiving diet alone or diet and oral hypoglycaemic agents. Each drug was given for one month in a double-blind, cross-over study. Fasting, noon, and mid-afternoon blood sugar concentrations rose by 1.0-1.5 mmol/l (18-27 mg/100 ml). The rise with propranolol was not significantly greater than with metoprolol. In a few patients the rise was clinically important. The small overall change observed in diabetic control should not deter the use of beta-blockers in non-insulin-dependent diabetics, provided control is carefully monitored at the onset of treatment.
摘要
在20名仅接受饮食治疗或饮食及口服降糖药治疗的高血压糖尿病患者中，比较了相对心脏选择性β受体阻滞剂美托洛尔和非选择性药物普萘洛尔对糖尿病控制的影响。在一项双盲交叉研究中，每种药物给药一个月。空腹、中午和下午血糖浓度升高1.0 - 1.5 mmol/l（18 - 27 mg/100 ml）。普萘洛尔引起的升高并不显著高于美托洛尔。在少数患者中，这种升高具有临床意义。在糖尿病控制方面观察到的总体变化较小，但只要在治疗开始时仔细监测控制情况，就不应妨碍在非胰岛素依赖型糖尿病患者中使用β受体阻滞剂。
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