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多囊卵巢综合征之谜:为获得最佳治疗而整合各方观点。

The PCOS puzzle: putting the pieces together for optimal care.

机构信息

Department of Pharmacology, CT Institute of Pharmaceutical Sciences, PTU, Jalandhar, Punjab, India.

Department of Pharmaceutical Sciences, University Of Kashmir, Srinagar, Jammu and Kashmir, India.

出版信息

Int J Adolesc Med Health. 2023 Aug 21;35(4):299-311. doi: 10.1515/ijamh-2023-0102. eCollection 2023 Aug 1.

Abstract

Polycystic ovary syndrome (PCOS) is a multifaceted hormonal disorder that has significant ramifications for both women's reproductive and metabolic well-being. This analysis aims to offer a thorough comprehension of PCOS by investigating the various contributing factors that are crucial for its effective management. We delve into the topic of hormonal imbalances, such as elevated androgens and disrupted estrogen-progesterone dynamics, and their effects on reproductive and metabolic health. Furthermore, we explore the intricate connection between insulin resistance, hyperinsulinemia, and PCOS, highlighting their pivotal role in metabolic dysfunction. Additionally, we examine fertility challenges, irregular menstrual patterns, and metabolic complications while also reviewing current treatment methodologies. Moreover, we address the latest research concerning genetic, environmental, and epigenetic influences on PCOS. By piecing together these essential elements, healthcare professionals can attain a comprehensive understanding of PCOS and deliver optimal care for those affected by the condition.

摘要

多囊卵巢综合征(PCOS)是一种多方面的激素紊乱疾病,对女性的生殖和代谢健康都有重大影响。本分析旨在通过研究对其有效管理至关重要的各种因素,来全面了解 PCOS。我们深入探讨了激素失衡的问题,如雄激素升高和雌激素-孕激素动态失调,以及它们对生殖和代谢健康的影响。此外,我们还探讨了胰岛素抵抗、高胰岛素血症与 PCOS 之间的复杂关系,强调了它们在代谢功能障碍中的关键作用。我们还检查了生育挑战、不规律的月经模式和代谢并发症,同时还回顾了当前的治疗方法。此外,我们还探讨了最新的研究结果,包括 PCOS 的遗传、环境和表观遗传影响。通过综合这些重要因素,医疗保健专业人员可以全面了解 PCOS,并为受该疾病影响的患者提供最佳护理。

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