Edmonds M S, Baker D H
J Anim Sci. 1986 Aug;63(2):533-7. doi: 10.2527/jas1986.632533x.
Three experiments were conducted to investigate the roxarsone (3-nitro-4-hydroxyphenylarsonic acid) X copper (Cu) interaction in weanling pigs. Supplemental roxarsone at 400 mg/kg diet decreased rate and efficiency of weight gain and caused visible neurological signs of toxicosis. Copper addition (CuSO4 X 5H2O) at a level of 650 mg Cu/kg diet likewise decreased weight gain and feed efficiency, and it also increased hepatic Cu deposition. The combination of these growth-depressing dosages of roxarsone and Cu resulted in a far greater reduction in gain and efficiency of feed utilization than was the case when either compound was fed alone. A growth-promoting dosage of Cu (250 mg/kg) increased weight gain by 32% in one experiment but showed no efficacy in alleviating the growth-depression resulting from feeding 400 mg/kg roxarsone. A roxarsone dosage of 100 mg/kg increased gain and feed efficiency. Surprisingly, the decreased weight gain in pigs fed 650 mg/kg Cu was ameliorated by feeding 100 mg/kg roxarsone concomitantly. This level of roxarsone also reduced liver Cu concentration substantially. It thus appears that the nature of the roxarsone X Cu interaction is dependent on the dose of each compound administered. Moreover, low-dose roxarsone administration appears to ameliorate Cu toxicity, but low-dose Cu feeding does not show efficacy against roxarsone toxicity.
进行了三项试验，以研究断奶仔猪中洛克沙胂（3-硝基-4-羟基苯胂酸）与铜（Cu）的相互作用。在日粮中添加400mg/kg的洛克沙胂会降低增重速度和效率，并导致明显的中毒神经症状。添加水平为650mg Cu/kg日粮的铜（CuSO₄·5H₂O）同样会降低增重和饲料效率，并且还会增加肝脏铜沉积。洛克沙胂和铜的这些抑制生长剂量组合导致的增重和饲料利用率下降幅度，比单独饲喂任何一种化合物时都要大得多。在一项试验中，促生长剂量的铜（250mg/kg）使增重提高了32%，但在缓解饲喂400mg/kg洛克沙胂导致的生长抑制方面没有效果。100mg/kg的洛克沙胂剂量提高了增重和饲料效率。令人惊讶的是，同时饲喂100mg/kg洛克沙胂可改善饲喂650mg/kg铜的猪的体重减轻情况。这个水平的洛克沙胂还显著降低了肝脏铜浓度。因此，洛克沙胂与铜相互作用的性质似乎取决于每种化合物的给药剂量。此外，低剂量洛克沙胂给药似乎可改善铜中毒，但低剂量铜饲喂对洛克沙胂中毒没有效果。
