Czarnecki G L, Edmonds M S, Izquierdo O A, Baker D H
J Anim Sci. 1984 Oct;59(4):997-1002. doi: 10.2527/jas1984.594997x.
Experiments were conducted to examine the effect of dietary roxarsone (3-nitro-4-hydroxyphenylarsonic acid) on Cu utilization by the pig, chick and rat. A fortified corn-soybean meal diet was fed in each experiment. Roxarsone dramatically reduced liver Cu concentration at all levels of supplemental Cu fed. The level of roxarsone commonly fed, 50 mg/kg diet, resulted in a two- to fourfold depression in liver Cu concentration in all species studied. The effects of roxarsone on weight gain were more perplexing. In the chick, the diets containing 100 and 250 mg Cu/kg depressed growth in the presence, but not in the absence, of 50 mg/kg dietary roxarsone. In contrast, at toxic levels of Cu, roxarsone had no effect on (500 or 750 mg Cu/kg diet) or slightly alleviated (1,000 mg Cu/kg diet) the growth-depressing effects of Cu. In the rat, a roxarsone level of 50 mg/kg diet exacerbated the growth-depressing effect of 1,000 mg Cu/kg diet. However, Cu had no effect on the growth depression that resulted from feeding a toxic level of roxarsone (250 mg/kg diet). The antagonizing effects of roxarsone and Cu on weight gain were not evident in the pig. Supplemental Cu (250 mg/kg diet) improved weight gain, but not feed efficiency, in starter pigs. Roxarsone (50 mg/kg diet) had no effect on the growth-promoting effects of Cu.
开展了多项实验，以研究日粮中洛克沙胂（3-硝基-4-羟基苯胂酸）对猪、鸡和大鼠铜利用情况的影响。每项实验均投喂强化玉米-豆粕日粮。在所有添加铜的水平下，洛克沙胂均显著降低了肝脏铜浓度。在所有受试物种中，日粮中常见的洛克沙胂添加水平（50毫克/千克日粮）导致肝脏铜浓度降低了两到四倍。洛克沙胂对体重增加的影响更为复杂。在鸡中，日粮中含100和250毫克铜/千克时，在添加50毫克/千克日粮洛克沙胂的情况下会抑制生长，而在不添加时则不会。相反，在铜达到中毒水平时，洛克沙胂对生长的抑制作用无影响（日粮含500或750毫克铜/千克）或略有缓解（日粮含1000毫克铜/千克）。在大鼠中，日粮中50毫克/千克的洛克沙胂水平加剧了日粮中1000毫克铜/千克对生长的抑制作用。然而，铜对因投喂中毒水平洛克沙胂（250毫克/千克日粮）导致的生长抑制无影响。洛克沙胂和铜对猪体重增加的拮抗作用不明显。日粮中添加铜（250毫克/千克）可提高仔猪的体重增加，但对饲料效率无影响。洛克沙胂（50毫克/千克日粮）对铜的促生长作用无影响。
