Merrill Lisa C, Mangano Kelsey M
Department of Public Health, University of Massachusetts Lowell, 61 Wilder Street, O'Leary 540, Lowell, MA, 01854, USA.
Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, 3 Solomont Way, Suite 4, Lowell, MA, 01854, USA.
Curr Osteoporos Rep. 2023 Oct;21(5):578-591. doi: 10.1007/s11914-023-00813-7. Epub 2023 Aug 19.
The purpose of this review is to summarize the scientific evidence published in the past 5 years examining the epidemiology of bone health as it relates to the gut microbiome, across race and ethnicity groups.
The link between the gut microbiome and bone health is well established and is supported by numerous biological mechanisms. However, human study research in this field is dominated by studies of older adults residing in Asian countries. A limited number of epidemiological and randomized controlled trials have been conducted with individuals in other countries; however, they are marked by their racial and ethnic homogeneity, use varied measures of the gut microbiome, and different interventions (where applicable), making comparisons across race and ethnic groups difficult. As the global prevalence of osteoporosis increases, the need for lifestyle interventions is critical. Existing data suggest that racial and ethnic differences in gut microbiome exist. Studies examining the relation between bone health and gut microbial structure and function across diverse racial and ethnic groups are needed to determine appropriate microbiome-based interventions.
本综述旨在总结过去5年发表的科学证据，这些证据研究了与肠道微生物群相关的骨骼健康流行病学，涉及不同种族和族裔群体。
肠道微生物群与骨骼健康之间的联系已得到充分证实，并得到众多生物学机制的支持。然而，该领域的人体研究主要集中在亚洲国家的老年人。其他国家针对个体开展的流行病学和随机对照试验数量有限；然而，这些研究的特点是种族和族裔单一，对肠道微生物群的测量方法各异，干预措施（如适用）也不同，这使得跨种族和族裔群体进行比较变得困难。随着全球骨质疏松症患病率的增加，生活方式干预的需求至关重要。现有数据表明，肠道微生物群存在种族和族裔差异。需要开展研究，考察不同种族和族裔群体中骨骼健康与肠道微生物结构和功能之间的关系，以确定合适的基于微生物群的干预措施。
