Institut de Neurosciences de la Timone, Aix Marseille Université, UMR 7289 CNRS, Marseille 13005, France.
Institute of Neuroscience and Medicine (INM-1), Forschungszentrum Jülich, Jülich, Germany.
Neuroimage. 2023 Oct 1;279:120336. doi: 10.1016/j.neuroimage.2023.120336. Epub 2023 Aug 18.
Group level analyses of functional regions involved in voice perception show evidence of 3 sets of bilateral voice-sensitive activations in the human prefrontal cortex, named the anterior, middle and posterior Frontal Voice Areas (FVAs). However, the relationship with the underlying sulcal anatomy, highly variable in this region, is still unknown. We examined the inter-individual variability of the FVAs in conjunction with the sulcal anatomy. To do so, anatomical and functional MRI scans from 74 subjects were analyzed to generate individual contrast maps of the FVAs and relate them to each subject's manually labeled prefrontal sulci. We report two major results. First, the frontal activations for the voice are significantly associated with the sulcal anatomy. Second, this correspondence with the sulcal anatomy at the individual level is a better predictor than coordinates in the MNI space. These findings offer new perspectives for the understanding of anatomical-functional correspondences in this complex cortical region. They also shed light on the importance of considering individual-specific variations in subject's anatomy.
群体水平的语音感知功能区域分析表明，人类前额叶皮质中存在三组双侧语音敏感激活区，分别命名为前、中、后额语音区（FVAs）。然而，与该区域高度可变的脑回解剖结构之间的关系仍不清楚。我们研究了 FVA 与脑回解剖结构的个体间变异性。为此，我们对 74 名受试者的解剖和功能磁共振成像扫描进行了分析，以生成 FVA 的个体对比图，并将其与每个受试者手动标记的前额叶脑回相关联。我们报告了两个主要结果。首先，语音的额部激活与脑回解剖结构显著相关。其次，这种与个体水平脑回解剖结构的对应关系比 MNI 空间中的坐标更能预测。这些发现为理解这一复杂皮质区域的解剖-功能对应关系提供了新的视角。它们还揭示了考虑受试者解剖结构个体差异的重要性。
