Departamento de Odontologia, Universidade de Taubaté, Brazil; Odontologia, Centro Universitário Braz Cubas, Brazil.
Departamento de Odontologia, Universidade de Taubaté, Brazil.
Photodiagnosis Photodyn Ther. 2023 Dec;44:103753. doi: 10.1016/j.pdpdt.2023.103753. Epub 2023 Aug 18.
Currently, the potential of FT-IR spectroscopy for rapid diagnosis of many pathologies has been demonstrated by numerous research studies including those targeting COVID-19 detection. However, the number of clinicians aware of this potential and who are willing to use spectroscopy in their clinics and hospitals is still negligible. In addition, lack of awareness creates a huge gap between clinicians and researchers involved in clinical translation of current FT-IR technology hence hindering initiatives to bring basic and applied research together for the direct benefit of patients.
Knowledge and medical training on FT-IR on the side of clinicians should be one of the first steps to be able to integrate it into the list of complementary exams which may be requested by health professionals. Countless FT-IR applications could have a life-changing impact on patients' lives, especially screening and diagnostic tests involving biofluids such as blood, saliva and urine which are routinely non-invasively or minimally-invasively.
Blood may be the most difficult to obtain by the invasive method of collection, but much can be evaluated in its components, and areas such as hematology, infectiology, oncology and endocrinology can be directly benefited. Urine with a relatively simple collection method can provide pertinent information from the entire urinary system, including the actual condition of the kidneys. Saliva collection can be simpler for the patient and can provide information on diseases affecting the mouth and digestive system and can be used to diagnose diseases such as oral cancer in its early-stages. An unavoidable second step is the active involvement of industries to design robust and portable instruments for specific purposes, as the medical community requires user-friendly instruments of advanced computational algorithms. A third step resides in the legal situation involving the global use of the technique as a new diagnostic modality.
It is important to note that decentralized funds for variety of technologies hinders the training of clinical and medical professionals for the use of newly arising technologies and affect the engagement of these professionals with technology developers. As a result of decentralized funding, research efforts are spread out over a range of technologies which take a long time to get validated and translated to the clinic. Partnership over similar groups of technologies and efforts to test the same technologies while overcoming barriers posed to technology validation in different areas around the globe may benefit the clinical/medical, research and industry community globally.
目前，傅里叶变换红外（FT-IR）光谱技术已经通过许多研究证明了其在快速诊断多种疾病方面的潜力，包括针对 COVID-19 检测的研究。然而，意识到这种潜力并愿意在诊所和医院中使用光谱技术的临床医生数量仍然微不足道。此外，缺乏意识在参与当前 FT-IR 技术临床转化的临床医生和研究人员之间造成了巨大的差距，从而阻碍了将基础研究和应用研究结合起来直接惠及患者的举措。
临床医生应该了解 FT-IR 的相关知识和医疗培训，以便将其纳入可能由卫生专业人员要求的补充检查清单中。无数的 FT-IR 应用可能会对患者的生活产生改变命运的影响，特别是涉及血液、唾液和尿液等生物流体的筛查和诊断测试，这些测试通常是非侵入性或微创性的。
血液可能是最难以通过侵入性采集方法获得的，但可以评估其成分中的大量信息，并且血液学、传染病学、肿瘤学和内分泌学等领域可以直接受益。尿液采集方法相对简单，可以提供整个泌尿系统的相关信息，包括肾脏的实际状况。唾液采集对患者来说更简单，可以提供有关影响口腔和消化系统疾病的信息，并可用于诊断口腔癌等早期疾病。不可避免的第二步是行业的积极参与，以设计针对特定用途的坚固、便携仪器，因为医疗界需要用户友好的、具有先进计算算法的仪器。第三步在于涉及将该技术作为新诊断模式在全球范围内使用的法律情况。
需要注意的是，分散的资金用于各种技术会阻碍临床和医疗专业人员对新兴技术的使用培训，并影响这些专业人员与技术开发人员的合作。由于分散的资金，研究工作分散在一系列需要很长时间才能得到验证并转化为临床应用的技术上。在相似的技术群组之间建立合作关系，并在克服全球不同地区技术验证障碍的同时测试相同的技术，可能会使全球临床/医学、研究和行业社区受益。
