Saint Antoine Hospital, Assistance publique des Hôpitaux de Paris (AP-HP), Paris, France.
Sleep Disorder Unit, Pitié-Salpêtrière Hospital and Sorbonne University, Paris, France; National Reference Network for Orphan Diseases: Narcolepsy and Rare Hypersomnias, Paris, France.
Rev Neurol (Paris). 2023 Oct;179(7):755-766. doi: 10.1016/j.neurol.2023.07.005. Epub 2023 Aug 17.
Sleepiness is a frequent and underrecognized symptom in neurological disorders, that impacts functional outcomes and quality of life. Multiple and potentially additive factors might contribute to sleepiness in neurological disorders, including sleep quality alterations, circadian rhythm disorders, drugs, and sleep disorders including sleep apnea or central disorders of hypersomnolence. Physician awareness of the possible symptoms of hypersomnolence, and associated causes is of crucial importance to allow proper identification and treatment of underlying causes. This review first provides a brief overview on clinical aspects of excessive daytime sleepiness, and diagnosis tools, then examines its frequency and mechanisms in various neurological disorders, including neurodegenerative disorders, multiple sclerosis, autoimmune encephalitis, epilepsy, and stroke.
困倦是神经系统疾病中常见且未被充分认识的症状，会影响功能结局和生活质量。多种潜在的、可能具有累加作用的因素可导致神经系统疾病中的困倦，包括睡眠质量改变、昼夜节律紊乱、药物以及睡眠呼吸暂停或中枢性嗜睡症等睡眠障碍。医生对过度日间嗜睡的可能症状及相关病因的认识至关重要，这有助于正确识别和治疗潜在病因。本综述首先简要概述日间过度嗜睡的临床特征和诊断工具，然后探讨其在各种神经系统疾病中的发生频率和机制，包括神经退行性疾病、多发性硬化症、自身免疫性脑炎、癫痫和中风。
