Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225009, China.
Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou, 225009, China.
J Nanobiotechnology. 2023 Aug 19;21(1):281. doi: 10.1186/s12951-023-02034-7.
Iron sulfide nanomaterials have been successfully employed as therapeutic agents for bacterial infection therapy and catalytic-ferroptosis synergistic tumor therapy due to their unique structures, physiochemical properties, and biocompatibility. However, biomedical research and understanding of the biological functions of iron sulfides are insufficient, and how iron sulfide nanomaterials affect reactive oxygen species (ROS) in diseases remains unknown. Acute kidney injury (AKI) is associated with high levels of ROS, and therefore nanomedicine-mediated antioxidant therapy has emerged as a novel strategy for its alleviation.
Here, mackinawite nanozymes were synthesized from glutathione (GSH) and iron ions (Fe) (denoted as GFeSNs) using a hydrothermal method, and then evaluated as ROS scavengers for ROS-related AKI treatment. GFeSNs showed broad-spectrum ROS scavenging ability through synergistic interactions of multiple enzymes-like and hydrogen polysulfide-releasing properties. Furthermore, both in vitro and in vivo experiments demonstrated that GFeSNs exhibited outstanding cytoprotective effects against ROS-induced damage at extremely low doses and significantly improved treatment outcomes in AKI.
Given the synergetic antioxidant properties and high biocompatibility, GFeSNs exhibit great potential for the treatment of AKI and other ROS-associated diseases.
由于独特的结构、物理化学性质和生物相容性，硫化亚铁纳米材料已成功用作治疗细菌感染和催化铁死亡协同肿瘤治疗的治疗剂。然而，生物医学研究和对硫化亚铁的生物学功能的理解还不够充分，并且尚不清楚铁硫化物纳米材料如何影响疾病中的活性氧 (ROS)。急性肾损伤 (AKI) 与高水平的 ROS 有关，因此，纳米医学介导的抗氧化治疗已成为缓解 AKI 的一种新策略。
本研究使用水热法从谷胱甘肽 (GSH) 和铁离子 (Fe) 合成了磁黄铁矿纳米酶 (GFeSNs)，并将其评估为用于 ROS 相关 AKI 治疗的 ROS 清除剂。GFeSNs 通过多种酶样和氢多硫化物释放特性的协同相互作用，具有广谱的 ROS 清除能力。此外，体内外实验均表明，GFeSNs 在极低剂量下对 ROS 诱导的损伤表现出出色的细胞保护作用，并显著改善 AKI 的治疗效果。
鉴于协同抗氧化特性和高生物相容性，GFeSNs 在治疗 AKI 和其他与 ROS 相关的疾病方面具有巨大潜力。
