Mukhopadhyay Subhankar, Veroniaina Hanitrarimalala, Chimombe Tadious, Han Lidong, Zhenghong Wu, Xiaole Qi
Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University Nanjing 210009 PR China
RSC Adv. 2019 Nov 1;9(61):35566-35578. doi: 10.1039/c9ra06127d. eCollection 2019 Oct 31.
Protean mesoporous silica nanoparticles (MSNs) are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including (but not limited to) changeable pore size, mesoporosity, high drug loading capacity, and biodegradability. MSNs have been drawing considerable attention as competent, safer and effective drug delivery vehicles day by day by their towering mechanical, chemical and thermal characteristics. Straightforward and easy steps are involved in the synthesis of MSNs at a relatively cheaper cost. This review reports Stober's synthesis, the first proposed synthesis procedure to prepare micron-sized, spherical MSNs, followed by other modifications later on done by scientists. To ensure the safety and compatibility of MSNs with biological systems, the hemocompatibility evaluation of MSNs using human red blood cells (RBCs) is a widely welcomed exercise. Though our main vision of this overview is to emphasize more on the hemocompatibility of MSNs to RBCs, we also brief about the synthesis and widespread applications of multifaceted MSNs. The strike of different parameters of MSNs plays a crucial role concerning the hemolytic activity of MSNs, which also has been discussed here. The inference is derived by centering some feasible measures that can be adopted to cut down or stop the hemolytic activity of MSNs in the future.
几十年来，多变的介孔二氧化硅纳米颗粒（MSNs）因其独特的特性（包括但不限于可变的孔径、介孔率、高载药量和生物可降解性），一直是纳米级药物递送系统的理想候选材料。MSNs凭借其出色的机械、化学和热学特性，日益成为高效、安全且有效的药物递送载体，备受关注。MSNs的合成步骤简单易行，成本相对较低。本综述报道了施托伯合成法，这是首次提出的制备微米级球形MSNs的合成方法，随后科学家们又进行了其他改进。为确保MSNs与生物系统的安全性和兼容性，使用人类红细胞（RBCs）对MSNs进行血液相容性评估是一项广受欢迎的工作。尽管本综述的主要目的是更加强调MSNs对RBCs的血液相容性，但我们也简要介绍了多功能MSNs的合成及广泛应用。MSNs的不同参数对其溶血活性起着关键作用，本文也对此进行了讨论。通过聚焦一些可行的措施得出推论，这些措施可在未来用于降低或阻止MSNs的溶血活性。
