Dept. of General Practice, Erasmus MC University Medical Center Rotterdam, the Netherlands.
Dept. of Radiology & Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, the Netherlands.
Osteoarthritis Cartilage. 2023 Dec;31(12):1644-1649. doi: 10.1016/j.joca.2023.08.003. Epub 2023 Aug 19.
To explore factors that were associated with meniscus volume in knees free of radiographic osteoarthritis (OA) features and symptoms of OA.
In the third Rotterdam Study cohort, clinical, radiographic, and magnetic resonance data were obtained at baseline (BL) and after 5 years of follow-up. Meniscus volumes and their change over time were calculated after semi-automatic segmentation on Magnetic Resonance Imaging. Knees with radiographic OA features (Kellgren and Lawrence>0) or clinical diagnosis of OA (American College of Rheumatology) at BL were excluded. Ten OA risk factors were adjusted in the multivariable analysis (generalized estimating equations), treating two knees within subjects as repeated measurements.
From 1065 knees (570 subjects), the average (standard deviation) age and Body mass index (BMI) of included subjects were 54.3 (3.7) years and 26.5 (4.4) kg/m. At BL, nine factors (varus alignment, higher BMI, meniscus pathologies, meniscus extrusion, cartilage lesions, injury, greater physical activity level, quadriceps muscle strength, and higher age) were significantly associated with greater meniscus volume. Five factors (injury, meniscus pathologies, meniscus extrusion, higher age, and change of BMI) were significantly associated with meniscus volume loss.
Modifiable factors (varus alignment, BMI, physical activity level, and quadriceps muscle strength) and non-modifiable factors (higher age, injury, meniscus pathologies, meniscus extrusion, and cartilage lesions) were all associated with meniscus volume or meniscus volume loss over time.
探讨与无放射影像学骨关节炎（OA）特征且无 OA 症状的膝关节半月板体积相关的因素。
在第三版鹿特丹研究队列中，在基线（BL）和随访 5 年后获得了临床、放射影像学和磁共振数据。在磁共振成像上进行半自动分割后计算半月板体积及其随时间的变化。排除 BL 时具有放射影像学 OA 特征（Kellgren 和 Lawrence>0）或临床 OA 诊断（美国风湿病学会）的膝关节。在多变量分析（广义估计方程）中调整了 10 个 OA 风险因素，将两个膝关节作为重复测量。
从 1065 个膝关节（570 名受试者）中，纳入受试者的平均（标准差）年龄和体重指数（BMI）分别为 54.3（3.7）岁和 26.5（4.4）kg/m。BL 时，9 个因素（内翻畸形、较高 BMI、半月板病变、半月板外突、软骨损伤、损伤、较高的体力活动水平、股四头肌力量和较高年龄）与较大的半月板体积显著相关。5 个因素（损伤、半月板病变、半月板外突、较高年龄和 BMI 变化）与半月板体积丢失显著相关。
可改变因素（内翻畸形、BMI、体力活动水平和股四头肌力量）和不可改变因素（较高年龄、损伤、半月板病变、半月板外突和软骨损伤）均与半月板体积或半月板体积随时间的丢失相关。
