Kinoshita Chisato, Kubota Noriko, Aoyama Koji
Department of Pharmacology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.
Teikyo University Support Center for Women Physicians and Researchers, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.
Int J Mol Sci. 2021 May 18;22(10):5292. doi: 10.3390/ijms22105292.
The number of patients with neurodegenerative diseases (NDs) is increasing, along with the growing number of older adults. This escalation threatens to create a medical and social crisis. NDs include a large spectrum of heterogeneous and multifactorial pathologies, such as amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease and multiple system atrophy, and the formation of inclusion bodies resulting from protein misfolding and aggregation is a hallmark of these disorders. The proteinaceous components of the pathological inclusions include several RNA-binding proteins (RBPs), which play important roles in splicing, stability, transcription and translation. In addition, RBPs were shown to play a critical role in regulating miRNA biogenesis and metabolism. The dysfunction of both RBPs and miRNAs is often observed in several NDs. Thus, the data about the interplay among RBPs and miRNAs and their cooperation in brain functions would be important to know for better understanding NDs and the development of effective therapeutics. In this review, we focused on the connection between miRNAs, RBPs and neurodegenerative diseases.
随着老年人数量的增加，神经退行性疾病（NDs）患者的数量也在上升。这种增长态势有可能引发一场医疗和社会危机。神经退行性疾病包括一系列广泛的异质性和多因素病理学病症，如肌萎缩侧索硬化症、额颞叶痴呆、阿尔茨海默病、帕金森病、亨廷顿舞蹈症和多系统萎缩症，而由蛋白质错误折叠和聚集形成的包涵体是这些病症的一个标志。病理性包涵体的蛋白质成分包括几种RNA结合蛋白（RBPs），它们在剪接、稳定性、转录和翻译中发挥重要作用。此外，RNA结合蛋白在调节微小RNA（miRNA）的生物合成和代谢中也起着关键作用。在几种神经退行性疾病中经常观察到RNA结合蛋白和微小RNA的功能障碍。因此，了解RNA结合蛋白和微小RNA之间的相互作用及其在脑功能中的协同作用的数据，对于更好地理解神经退行性疾病和开发有效的治疗方法至关重要。在这篇综述中，我们重点关注了微小RNA、RNA结合蛋白与神经退行性疾病之间的联系。
