Weng Guihu, Tao Jinxin, Liu Yueze, Qiu Jiangdong, Su Dan, Wang Ruobing, Luo Wenhao, Zhang Taiping
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan, Wangfujing Street, Beijing, 100730, China.
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan, Wangfujing Street, Beijing, 100730, China.
Cancer Lett. 2023 Sep 28;572:216353. doi: 10.1016/j.canlet.2023.216353. Epub 2023 Aug 18.
Nowadays, the diagnosis and treatment system of malignant tumors has increasingly tended to be more precise and personalized while the existing tumor models are still unable to fully meet the needs of clinical practice. Notably, the emerging organoid platform has been proven to have huge potential in the field of basic-translational medicine, which is expected to promote a paradigm shift in personalized medicine. Here, given the unique advantages of organoid platform, we mainly explore the prominent role of organoid models in basic research and clinical practice from perspectives of tumor biology, tumorigenic microbes-host interaction, clinical decision-making, and regenerative strategy. In addition, we also put forward some practical suggestions on how to construct a new generation of organoid platform, which is destined to vigorously promote the reform of basic-translational medicine.
如今，恶性肿瘤的诊断和治疗系统越来越趋向于更加精准和个性化，而现有的肿瘤模型仍无法完全满足临床实践的需求。值得注意的是，新兴的类器官平台已被证明在基础转化医学领域具有巨大潜力，有望推动个性化医疗的范式转变。在此，鉴于类器官平台的独特优势，我们主要从肿瘤生物学、致瘤微生物与宿主相互作用、临床决策和再生策略等角度探讨类器官模型在基础研究和临床实践中的突出作用。此外，我们还就如何构建新一代类器官平台提出了一些切实可行的建议，这注定将大力推动基础转化医学的变革。
