Institute of Basic Medical Sciences, National Cheng Kung University Hospital, 1 University Road, Tainan 70101, Taiwan.
Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, 1 University Road, Tainan 70101, Taiwan.
Trends Mol Med. 2023 Oct;29(10):780-782. doi: 10.1016/j.molmed.2023.08.003. Epub 2023 Aug 18.
Recent work by Muraoka and colleagues reports that the Gram-negative anaerobic bacterium Fusobacterium nucleatum is detected in the uterus of 64% of women with endometriosis. Fusobacterium infection causes macrophage infiltration, transforming growth factor-β production, and transgelin upregulation in human and mouse endometria as well as endometriotic lesion development in a mouse model of endometriosis.
最近，Muraoka 及其同事的研究报告称，革兰氏阴性厌氧细菌具核梭杆菌存在于 64%的子宫内膜异位症女性的子宫中。具核梭杆菌感染导致人类和小鼠子宫内膜中巨噬细胞浸润、转化生长因子-β产生和转胶蛋白上调，以及子宫内膜异位症小鼠模型中子宫内膜异位症病变的发展。
