Li Haoying, Wang Lu, Feng Jinhong, Jiang Lijuan, Wu Jingping
Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Department of Medical Cosmetology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Nutr. 2023 Aug 4;10:1232229. doi: 10.3389/fnut.2023.1232229. eCollection 2023.
In recent years, oral various fruits or supplements of fruits natural extracts have been reported to have significant anti-aging effects on the skin (1, 2), However, despite many studies on this topic, there is often no clear evidence to support their efficacy and safety. In this paper, we present a comprehensive review and Meta-analysis of the evidence for the safety and efficacy of oral fruits and fruits extracts in improving skin aging.
Four databases, Pubmed, Embase, Web of Science, and Cochrane Library (CENTRAL), were searched for relevant literature from 2000-01 to 2023-03. Seven randomized controlled trials (RCTs) of fruit intake or fruit extracts associated with anti-skin aging were screened for Meta-analysis.
Compared to placebo, oral intake of fruit or fruit extracts showed significant statistical differences in skin hydration and transepidermal water loss (TEWL), with a significant improvement in skin hydration and a significant decrease in TEWL. No significant statistical difference was observed in minimal erythema dose (MED), overall skin elasticity (R2), or wrinkle depth, and no evidence of significant improvement in skin condition was observed.
Meta-analysis results suggest that consume administration of fruits or fruit extracts significantly enhances skin hydration and reduces transcutaneous water loss, but there is insufficient evidence to support other outcome recommendations, including minimal erythema dose (MED), overall skin elasticity(R2), and wrinkle depth.
PROSPERO (york.ac.uk), identifier CRD42023410382.
近年来，有报道称口服各种水果或水果天然提取物对皮肤具有显著的抗衰老作用(1,2)。然而，尽管对此主题进行了许多研究，但往往没有明确的证据支持其有效性和安全性。在本文中，我们对口服水果和水果提取物改善皮肤老化的安全性和有效性证据进行了全面综述和荟萃分析。
检索了四个数据库，即PubMed、Embase、Web of Science和Cochrane图书馆（CENTRAL），以查找2000年1月至2023年3月的相关文献。筛选了七项与抗皮肤老化相关的水果摄入或水果提取物的随机对照试验（RCT）进行荟萃分析。
与安慰剂相比，口服水果或水果提取物在皮肤水合作用和经表皮水分流失（TEWL）方面显示出显著的统计学差异，皮肤水合作用显著改善，TEWL显著降低。在最小红斑剂量（MED）、整体皮肤弹性（R2）或皱纹深度方面未观察到显著的统计学差异，也未观察到皮肤状况有显著改善的证据。
荟萃分析结果表明，食用水果或水果提取物可显著增强皮肤水合作用并减少经皮水分流失，但没有足够的证据支持其他结果建议，包括最小红斑剂量（MED）、整体皮肤弹性（R2）和皱纹深度。
PROSPERO（york.ac.uk），标识符CRD42023410382。
