Biodiversity Research Institute, Jeju Technopark, Jeju 63608, Korea.
Nutrients. 2022 Mar 24;14(7):1352. doi: 10.3390/nu14071352.
Green mandarins are widely consumed unripe as mandarin oranges (), which exhibit anti-inflammatory and anti-wrinkle effects by inhibiting the production of inflammatory cytokines and matrix metalloproteinase. A randomized, double-blind, placebo-controlled clinical study was performed to verify the skin improvement efficacy and safety of green mandarin extract (PTE). For the standardization of PTE, narirutin was set as a marker compound, and PTE with a constant narirutin content was prepared for the study. After randomizing subjects with periorbital wrinkles, they were orally administered PTE (300 mg/day) or a placebo for 12 weeks. Periorbital wrinkles were measured using PRIMOS SF. Skin elasticity, moisture content, transepidermal water loss, and gloss were also measured. In the study results, the depth, volume, and skin roughness of the periorbital wrinkles were significantly improved compared to the control group ( = 0.011, 0.009, and 0.004, respectively). The survey confirmed that the skin condition improved after PTE consumption for 12 weeks. No adverse reactions associated with PTE were observed during the study period. Thus, the results demonstrate that PTE effectively improves UV-induced skin wrinkles. Therefore, it is considered that PTE has sufficient value as a functional food ingredient that can prevent skin aging.
青金桔作为一种未成熟的柑橘被广泛食用（），通过抑制炎症细胞因子和基质金属蛋白酶的产生，具有抗炎和抗皱作用。进行了一项随机、双盲、安慰剂对照的临床研究，以验证青金桔提取物（PTE）的皮肤改善功效和安全性。为了标准化 PTE，以柚皮苷为标记化合物，并制备了具有恒定柚皮苷含量的 PTE 用于研究。将患有眶周皱纹的受试者随机分组后，他们口服 PTE（300mg/天）或安慰剂 12 周。使用 PRIMOS SF 测量眶周皱纹。还测量了皮肤弹性、水分含量、经皮水分损失和光泽度。在研究结果中，与对照组相比，眶周皱纹的深度、体积和皮肤粗糙度均显著改善（=0.011、0.009 和 0.004）。调查证实，PTE 消费 12 周后皮肤状况得到改善。在研究期间未观察到与 PTE 相关的不良反应。因此，结果表明 PTE 可有效改善 UV 诱导的皮肤皱纹。因此，认为 PTE 作为一种功能性食品成分，具有预防皮肤衰老的足够价值。
