膳食补充剂对健康成年人皮肤光老化的有效性：一项随机对照试验的系统评价和荟萃分析

Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of randomized controlled trials.

作者信息

Yang Qifeng, Li Haoying, Zhang Hanxin, Ma Luyao, Zhang Xiaofeng, Wu Jingping

机构信息

Department of Medical Cosmetology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Baoji Traditional Chinese Medicine Hospital, Baoji, China.

出版信息

Front Med (Lausanne). 2025 Jul 21;12:1582946. doi: 10.3389/fmed.2025.1582946. eCollection 2025.

DOI:10.3389/fmed.2025.1582946

PMID:40761858

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12318760/

Abstract

BACKGROUND

The dietary supplement industry offers a wide range of orally consumed products that claim to combat skin photoaging, however, there is a lack of research on the proof of safety and effectiveness of dietary supplements in anti-skin photoaging. To further confirm their safety and efficacy, this article provides a detailed review and meta-analysis.

METHODS

Four databases, including PubMed, Embase, Web of Science, and the Cochrane Library (Central Database), were searched for relevant literature up to October 2024. A total of forty English-language randomized controlled trials (RCTs) investigating the relationship between dietary supplements and skin photoaging were screened for an in-depth review and meta-analysis.

RESULTS

Collagen, flavanols, and other polyphenol supplements have been found to alleviate skin photoaging and increase MED or overall skin elasticity (R2) when compared to a placebo. However, hyaluronic acid, lycopene, and carotenoids did not show any significant benefits in improving skin photoaging or MED/R2. Due to inconsistent findings and limited research, the effects of dietary supplements on skin photoaging could not be determined in randomized controlled trials with two or fewer studies. It is important to note that, during the study period (typically ≤ 24 weeks), all orally administered dietary supplements were found to be safe.

CONCLUSION

Oral dietary supplements, such as collagen, flavanols, and polyphenols, have demonstrated effectiveness in addressing skin photoaging. However, there is currently insufficient evidence to support the recommendation of other dietary supplements, such as astaxanthin, for the treatment of skin photoaging. This research serves as an initial step in exploring the benefits of dietary supplements in combating skin photoaging. It underscores the need for more focused studies to further investigate the effects of dietary supplements on skin photoaging and gather additional evidence supporting their efficacy.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/PROSPERO/view/CRD42023472473, identifier CRD42023472473.

摘要

背景

膳食补充剂行业提供了种类繁多的口服产品，声称可对抗皮肤光老化，然而，关于膳食补充剂抗皮肤光老化的安全性和有效性的研究却很缺乏。为进一步证实其安全性和有效性，本文进行了详细的综述和荟萃分析。

方法

检索了包括PubMed、Embase、Web of Science和Cochrane图书馆（核心数据库）在内的四个数据库，查找截至2024年10月的相关文献。共筛选出40项研究膳食补充剂与皮肤光老化关系的英文随机对照试验（RCT），进行深入综述和荟萃分析。

结果

与安慰剂相比，已发现胶原蛋白、黄烷醇和其他多酚类补充剂可减轻皮肤光老化，并增加最小红斑量（MED）或整体皮肤弹性（R2）。然而，透明质酸、番茄红素和类胡萝卜素在改善皮肤光老化或MED/R2方面未显示出任何显著益处。由于研究结果不一致且研究有限，在两项或更少研究的随机对照试验中，无法确定膳食补充剂对皮肤光老化的影响。需要注意的是，在研究期间（通常≤24周），所有口服的膳食补充剂均被发现是安全的。

结论

口服膳食补充剂，如胶原蛋白、黄烷醇和多酚，已证明在解决皮肤光老化方面有效。然而，目前尚无足够证据支持推荐其他膳食补充剂，如虾青素，用于治疗皮肤光老化。本研究是探索膳食补充剂对抗皮肤光老化益处的第一步。它强调需要进行更有针对性的研究，以进一步调查膳食补充剂对皮肤光老化的影响，并收集更多支持其疗效的证据。