Shibuta R, Tanaka M, Sisido M, Imanishi Y
J Biomed Mater Res. 1986 Sep;20(7):971-87. doi: 10.1002/jbm.820200712.
Novel polyaminoetherurethaneureas containing tertiary amino groups in the main chain were synthesized (PAEUU), quaternized (Q-PAEUU), and heparinized (H-PAEUU). Films of PAEUU showed a microphase separation, which was influenced by the quaternization and the heparinization. With increasing content of amino group, the water content of Q-PAEUU and the heparin content of H-PAEUU increased. The heparin-releasing rate from H-PAEUU into physiological saline solution was slow, but increased with increasing content of quaternary ammonium groups in the polymer. The water content, the heparin adsorption, and the heparin-releasing rate were controlled by the kind of quaternizing agent. The antithrombogenicity of the polyurethaneureas was improved by quaternization and very much by heparinization, and affected by the kind of quaternizing agent. Heparinization was indispensable for achieving antithrombogenicity of the polymer, although the antithrombogenicity of H-PAEUU was affected more strongly by the water content than by the heparin content. The surface free energy of these polymer films was also investigated.
合成了主链中含有叔氨基的新型聚氨基醚聚氨酯脲（PAEUU），对其进行了季铵化（Q-PAEUU）和肝素化（H-PAEUU）处理。PAEUU薄膜呈现微相分离，这受到季铵化和肝素化的影响。随着氨基含量的增加，Q-PAEUU的含水量和H-PAEUU的肝素含量增加。H-PAEUU在生理盐溶液中的肝素释放速率缓慢，但随着聚合物中季铵基团含量的增加而加快。含水量、肝素吸附量和肝素释放速率受季铵化剂种类的控制。聚氨酯脲的抗血栓形成性通过季铵化得到改善，通过肝素化得到极大改善，并且受季铵化剂种类的影响。肝素化对于实现聚合物的抗血栓形成性是必不可少的，尽管H-PAEUU的抗血栓形成性受含水量的影响比受肝素含量的影响更强。还研究了这些聚合物薄膜的表面自由能。
