Marconi W, Martinelli A, Piozzi A, Zane D
Department of Chemistry, University of Rome La Sapienza, Italy.
Biomaterials. 1992;13(7):432-8. doi: 10.1016/0142-9612(92)90163-i.
The synthesis of a new segmented polyurethane containing quaternary ammonium groups in the side-chain is reported. The quaternization was carried out both on the polymer dissolved in an organic solvent and on polymer films. Polymeric films quaternized by both techniques were heparinized. The amount of bonded heparin, determined by spectrophotometry, was remarkably higher than previously described. Polymer quaternized in solution bonded more heparin than that heparinized directly on film. In vitro evaluations of antithrombogenicity by activated partial thromboplastin time (APTT) carried out on the films confirmed these data. The polymers were also characterized by chemical, i.r., n.m.r., differential scanning calorimetry and viscometric techniques.
报道了一种侧链含季铵基团的新型嵌段聚氨酯的合成。季铵化反应在溶解于有机溶剂的聚合物上以及聚合物薄膜上均进行。通过这两种技术季铵化的聚合物薄膜均进行了肝素化处理。通过分光光度法测定的结合肝素量显著高于先前报道的量。在溶液中季铵化的聚合物比直接在薄膜上肝素化的聚合物结合更多的肝素。对薄膜进行的活化部分凝血活酶时间（APTT）体外抗血栓形成性评估证实了这些数据。还通过化学、红外、核磁共振、差示扫描量热法和粘度测定技术对聚合物进行了表征。
