Gabrielli Maurizio, Zaccaria Raffaella, Impagnatiello Michele, Zileri Dal Verme Lorenzo, Gasbarrini Antonio
Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Nutrients. 2024 Nov 21;16(23):3985. doi: 10.3390/nu16233985.
BACKGROUND/OBJECTIVES: Sepsis is a life-threatening condition characterized by an imbalanced immune response to infection, posing a significant challenge in hospital settings due to its high morbidity and mortality rates. While much attention has been given to patients in the ICU, uncertainties remain regarding the nutritional management of septic patients in non-intensive wards. This narrative review aims to address these gaps by exploring key aspects of nutritional care in sepsis patients admitted to non-intensive wards.
We examine the pathophysiological mechanisms driving metabolic alterations in sepsis, methods for effective nutritional assessment, and supplementation strategies, including the potential role of specific nutrients. Additionally, we discuss the preventive role of nutrition, with a focus on gut microbiota modulation.
By synthesizing the available literature, this review provides evidence-based insights to guide nutritional strategies for managing sepsis in patients hospitalized in non-intensive wards and highlights critical areas for future research.
背景/目的：脓毒症是一种危及生命的病症，其特征是对感染的免疫反应失衡，由于其高发病率和死亡率，在医院环境中构成了重大挑战。虽然重症监护病房（ICU）的患者受到了很多关注，但非重症病房中脓毒症患者的营养管理仍存在不确定性。本叙述性综述旨在通过探讨非重症病房中脓毒症患者营养护理的关键方面来填补这些空白。
我们研究了驱动脓毒症代谢改变的病理生理机制、有效的营养评估方法和补充策略，包括特定营养素的潜在作用。此外，我们讨论了营养的预防作用，重点是肠道微生物群调节。
通过综合现有文献，本综述提供了基于证据的见解，以指导非重症病房住院患者脓毒症管理的营养策略，并突出了未来研究的关键领域。
